Octapeptide vasopressin antagonists

Details Octapeptide vasopressin antagonists Octapeptide vasopressin antagonists

1984-06-26

1985-09-17

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

2601125R, 514807, A61K 3700, C07C10352

Patent

active

045421242

ABSTRACT:
Certain octapeptides, which have structures characterized by being a six unit cyclic peptide ring with a dipeptide tail which lacks a glycine unit at position 9, have potent vasopressin antagonist activity. The compounds here claimed are in general characterized by having an amino acid unit at position 4 which is other than valine. An important species of the group is [1-(.beta.-mercapto-.beta.,.beta.-cyclopentamethylenepropionic acid)-2-(O-ethyl-D-tyrosine)-4-.alpha.-aminobutyric acid-8-arginine-9-desglycine]vasopressin.

REFERENCES:
patent: 4367225 (1983-01-01), Manning et al.
patent: 4399125 (1983-08-01), Manning et al.
M. Manning et al., Nature, 308 652 (1984).
M. Manning et al., J. Med. Chem. 26, 1607-1613 (1983).

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