Octahydropyrido[1,2-c]pyrimidinones and hexahydropyrido[1,2-c]py

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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Details

544282, 546245, C07D47104, A61K 31505

Patent

active

046802959

ABSTRACT:
This invention relates to octahydropyrido[1,2-c]pyrimidinones and hexahydropyrido[1,2-c]pyrimidinediones that are useful as inhibitors of cardiac arrhythmias and are therefore useful in the treatment of irregular heartbeat.

REFERENCES:
patent: 4560754 (1985-12-01), Adelstein et al.
patent: 4567270 (1986-01-01), Chorvat et al.
L. S. Goodman & A. Gilman, eds., The Pharmacological Basis of Therapeutics, 6th Edition; New York: Macmillan Publishing Co., 1980: pp. 730-731, 750-751, 761-786.
R. J. Chorvat et al., "Synthesis and Structure Activity Relationships of a New Series of Antiarrhythmic Agents . . . ", J. Med. Chem., 28, 1285-1291 (1985).

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