Octahydronaphthyridine derivatives

Details Octahydronaphthyridine derivatives Octahydronaphthyridine derivatives

1996-04-03

1997-12-23

Ivy, C. Warren

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

514249, C07D47108, A61K 31445

Patent

active

057009414

ABSTRACT:
A class of substituted 1,2,3,4,5,6,7,8-octahydronaphthyridine derivatives are ligands for dopamine receptor subtypes within the body, in particular the D.sub.4 subtype, and are therefore useful in the treatment and/or prevention of disorders of the dopamine system, in particular schizophrenia or depression.

REFERENCES:
patent: 4786642 (1988-11-01), Teulon
patent: 5576319 (1996-11-01), Baker et al.
Boyfield, I. et al.; N-(substituted-Phenyl) Piperazines: Antagonists with high binding and functional selectivity for dopamine D.sub.4 receptors. Biorganic & Medicinal Chemistry Letters vol. 6, pp. 1227-1232, 1995.

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