Octahydronaphthalene oxime derivatives for cholesterol biosynthe

Details Octahydronaphthalene oxime derivatives for cholesterol biosynthe Octahydronaphthalene oxime derivatives for cholesterol biosynthe

1994-12-14

1997-02-18

Ramsuer, Robert W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544165, 548204, 548248, 549 71, 549 77, 549366, 549373, 549378, 549467, 549494, 560 73, 560107, 560252, A61K 31335, C07D31906

Patent

active

056042566

ABSTRACT:
Compounds of formula (I): ##STR1## (in which: R is hydrogen, methyl or hydroxy; X is alkyl, alkenyl, cycloalkyl, aryl, aralkyl, or a heterocyclic group; A is a single bond, or an alkylene, alkenylene, alkynylene or alkadienylene group; Y is hydrogen, aryl, cycloalkyl or a heterocyclic group) have the ability to inhibit the biosynthesis of cholesterol, and can thus be used for the treatment and prophylaxis of diseases relating to high blood cholesterol levels.

REFERENCES:
patent: 4997848 (1991-03-01), Kurabayashi et al.
Heathcock et al, "Synthesis and Biological Evaluation of a Monocyclic, Fully Functional Analogue of Compactin", J. Med. Chem., 32, 197-202, (1989).

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