Octahydronaphthalene oxime compounds for cholesterol synthesis i

Details Octahydronaphthalene oxime compounds for cholesterol synthesis i Octahydronaphthalene oxime compounds for cholesterol synthesis i

1990-12-14

1995-04-04

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514510, 549292, 560256, A61K 3135, C07D30930

Patent

active

054038600

ABSTRACT:
Compounds of formula (I): ##STR1## in which R is hydrogen, methyl or hydroxy; X is alkyl, alkenyl, cycloalkyl, aryl or aralkyl; A is a single bond or alkylene, alkenylene, alkynylene or alkadienylene and Y is aryl. The compounds have valuable antihypercholesteremic activities and can be used in the treatment of disorders arising from a blood cholesterol imbalance in humans and animals.

REFERENCES:
patent: 3983140 (1976-09-01), Endo
patent: 4604472 (1986-08-01), Ide
patent: 4733003 (1988-03-01), Ide
patent: 4997848 (1991-03-01), Kurabayashi
Heathcock, et al `Synthesis and Biological Evaluation of a Monocyclic Fully Functional Analogue of Compactin` J. Med. Chem 32 pp. 197-202 (1989).

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