Octahydronaphthalene oxime compounds for cholesterol synthesis i

Details Octahydronaphthalene oxime compounds for cholesterol synthesis i Octahydronaphthalene oxime compounds for cholesterol synthesis i

1995-03-07

1997-08-19

Owens, Amelia

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

5142315, 5142382, 514277, 514336, 514378, 514452, 514460, 514471, 514548, 514559, 549292, 549373, 549426, 549491, 549496, 548247, 5462821, 546339, 544149, 544159, 554110, 554221, 554229, A61K 3135, A61K 3120, A61K 3142, A61K 31435

Patent

active

056589425

ABSTRACT:
Compounds of formula (I): ##STR1## in which: R represents hydrogen, methyl or hydroxy; X represents an alkyl, alkenyl, cycloalkyl, aryl, aralkyl, or heterocyclic group; A represents a single bond, or an alkylene, alkenylene, alkynylene or alkadienylene group; Y represents hydrogen, or an aryl, cycloalkyl or heterocyclic group; have valuable antihypercholesteremic activities and may be used in the treatment of disorders arising from a blood cholesterol imbalance in humans and other animals.

REFERENCES:
patent: 3983140 (1976-09-01), Endo
patent: 4604472 (1986-08-01), Ide
patent: 4733003 (1988-03-01), Ide
patent: 4997848 (1991-03-01), Kurabayashi et al.
Heathcock et al, "Synthesis and Biological Evaluation of a Monocyclic, Fully Functional Analogue of Compactin", J. Med. Chem. (1989), pp. 197-202 .

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