Octahydronaphthalene derivatives and their preparation

Details Octahydronaphthalene derivatives and their preparation Octahydronaphthalene derivatives and their preparation

1985-07-09

1986-08-05

Hollrah, Glennon H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

514824, 562501, 560119, C07D30930

Patent

active

046044728

ABSTRACT:
Compounds of formula (I): ##STR1## [wherein X represents a hydrogen atom or a 2-methylbutyryl group, Y represents a hydrogen atom or a methyl group and R.sup.1 and R.sup.2 are the same or different and each represents an oxygen atom or a group of formula .dbd.N--OR.sup.3 (wherein R.sup.3 represents a hydrogen atom or an alkyl group)], the free hydroxy-carboxylic acids corresponding thereto and salts and esters of said acids may be prepared by oxidizing and, if necessary, oximating a corresponding ML-236A, ML-236B, MB-530A or MB-530B compound, and these compounds have valuable antihypercholesteraemic activity.

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patent: 4361515 (1982-11-01), Terahara et al.
patent: 4503072 (1985-03-01), Hoffman et al.
patent: 4517373 (1985-05-01), Terahara et al.
J. F. W. McOmie, Protective Groups in Organic Chemistry (1973), pp. 341-342.
Chemical Abstracts 93: 45280c.
B. Unterhalt, Pharmazeutische Zeitung, vol. 125(7) (1980), pp. 361-367.

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