Octahydroindolizinepropanoic acids and related compounds as enzy

Details Octahydroindolizinepropanoic acids and related compounds as enzy Octahydroindolizinepropanoic acids and related compounds as enzy

1986-06-05

1987-06-23

Brust, Joseph Paul

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546183, C07D20902, C07D22100

Patent

active

046754083

ABSTRACT:
Octahydro-5-oxoindolizine-6-propanoic acids and octahydro-6-oxopyrido[1,2-a]pyridine-7-propanoic acids, the decarboxy and related ester and perhydro derivatives thereof inhibit angiotensin I converting enzyme and are hypotensive agents. Hydrogenation of A58365 factors A and B, obtained by culturing Streptomyces chromofuscus, provides the ACE inhibitors. Also provided are O-acyl and O-sulfonyl derivatives of A and B factors which are useful in preparing deoxy factors A and B via hydrogenolysis.

REFERENCES:
patent: 3274202 (1966-09-01), Mohrbacher
patent: 3297704 (1967-01-01), Mohrbacher
patent: 3494929 (1970-02-01), Freed
patent: 4046889 (1977-09-01), Ondetti et al.
patent: 4154935 (1979-05-01), Ondetti et al.
patent: 4316905 (1982-02-01), Krapcho
patent: 4316906 (1982-02-01), Ondetti et al.
patent: 4404281 (1983-09-01), O'Connor et al.
patent: 4404282 (1983-09-01), Nakatsukasa
patent: 4508901 (1985-04-01), Mynderse et al.
Cushman, D. W., et al.; Federation Proceedings, vol. 38, No. 13; Dec. 1979; pp. 2779 & 2782.
Derwent et al., 25836 D/15 of E.P. 25-941, (.COPYRGT.1981),
A. A. Patchett, et al., Nature, 288, pp. 280-283, (1980).
E. D. Thorsett, et al.; "Dipeptide Mimics Conformationally Restricted Inhibitors of Angiotensin-Converting Enzyme", Biochemical and Biophysical Research Communications, vol. III, No. 1, Feb. 28, 1983, pp. 166-171.

Affiliated with

Also associated with

Rating

Octahydroindolizinepropanoic acids and related compounds as enzy does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Octahydroindolizinepropanoic acids and related compounds as enzy, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Octahydroindolizinepropanoic acids and related compounds as enzy will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-722244