Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1985-01-09
1986-04-15
Jiles, Henry R.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514241, 514242, 514254, 514256, 544180, 544182, 544238, 544336, 546112, A61D 31445, C07D22104
Patent
active
045828369
ABSTRACT:
Octahydroindolizidines of the formula (I): ##STR1## where A is a 3-7 carbon or hetero-containing ring, R.sup.1 is a substituent and x is 0-3. Also, pharmaceutical composition for treating pain and methods for synthesis and use as well as novel intermediates in the synthesis.
REFERENCES:
M. E. Rogers and Joseph Sam, Journal of Medicinal Chemistry, 18, 1126-1130 (1975).
"A Synthesis of Octahydropyrrocolines", Francis Lions et al., J. Pruc. Royal Soc. N.S. Wales 73:240-252 (1940).
Reinecke et al., "The Structures and Spectral Properties . . . " Departments of Chemistry, University of California, (1966), pp. 4215-4220, vol. 31.
I. Murakoshi in Chemical Abstracts, vol. 52, 18409b to 18410e (1958).
Yasutaka Nagal et al., Chem. Pharm. Bull., vol. 27, No. 5, pp. 1159-1168, (1979), Research Laboratory, Dainippon Phar. Co.
Stetter et al., J. Heterocyclic Chem., vol., 14, pp. 573-581, (1977), "Addition von Aldehyden . . . ".
Carmosin Richard J.
Carson John R.
Dentz Bernard I.
Jiles Henry R.
Levy David J.
McNeilab Inc.
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