Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1985-12-19
1987-12-08
Ramsuer, Robert W.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514229, 514230, 514231, 514232, 514233, 514236, 514253, 514300, 544 80, 544127, 544357, 544362, 546113, A61K 31435, A61K 31535, C07D47104
Patent
active
047118822
ABSTRACT:
A series of novel octahydro-6-azaindole dipeptide derivatives have been prepared, including their pharmaceutically acceptable salts and bioprecursors therefor. These particular compounds are inhibitors of the angiotensin converting enzyme and are therefore useful in therapy for the treatment of certain cardiovascular disorders, including heart failure and hypertension. Preferred member compounds include 1-[N-(1-S-ethoxycarbonyl-3-phenylpropyl)-S-alanyl]-2-S-carboxy-6-(N-methyl carbamoyl)-octahydro-6-azaindole, 1-[N-(1-S-ethoxycarbonyl-3-phenylpropyl-S-alanyl]-2-S-carboxy-6-methanesul phonyl-octahydro-6-azaindole and 1-[N-(1-carboxy-3-phenylpropyl)-S-lysyl]-2-carboxy-6-methanesulphonyl-octa hydro-6-azaindole, respectively. Methods for preparing these compounds from known starting materials are provided.
REFERENCES:
Published Australian Patent Application No. AU-A-23645/84.
Campbell Simon F.
Kobylecki Ryszard J.
Akers Lawrence C.
Lumb J. Trevor
Pfizer Inc.
Ramsuer Robert W.
Richardson Peter C.
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