Octahydro-2H-pyrido[1,2-a]pyrazine compounds

Details Octahydro-2H-pyrido[1,2-a]pyrazine compounds Octahydro-2H-pyrido[1,2-a]pyrazine compounds

2006-01-31

2006-01-31

Raymond, Richard L. (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C544S349000

Reexamination Certificate

active

06992085

ABSTRACT:
A compound selected from those of formula (I):wherein:Ra represents linear or branched (C1–C6)alkylene,X represents a group selected from W1, —C(W1)—W2—, —W2—C(W1)—, —W2—C(W1)W2—, —W2—Ra— and —CH(OR1)— wherein W1, W2and R1are as defined in the description, when Y represents aryl or heteroaryl,orX represents a group selected from single bond, —C(W1)—, —W2—C(W1)—, —W2—Ra and —CH(OR1)— wherein W1, W2, Ra and R1are as defined hereinbefore, when Y represents a fused bicyclic group, of formula:wherein:A represents nitrogen-containing heterocycle having from 4 to 7 ring members that is unsaturated or partially saturated and optionally contains a second hetero atom,B represents phenyl ring optionally substituted by one or more groups as defined in the description,its isomers, and addition salts thereof with a pharmaceutically acceptable acid or base, medicinal products containing the same are useful in the treatment of cognitive deficiencies.

REFERENCES:
patent: 3388128 (1968-06-01), Day
patent: 94/06794 (1994-03-01), None
Phillips et al. in Annual Reports in Medicinal Chemistry, vol. 33, p. 31-40 (1998).
Koshinaka et al.,Chemical Abstacts, vol. 87, No. 68417 (1977), Abstract for JP 5202188 (Jan. 29, 1977).
Horrigan, Exp.Opin. Pharmacother. vol. 2, p. 573-586 (2001).
Arrang, et al.,European Journal of Pharmacology—Molecular Pharmacology Section, 1990, 188, 219-227.
Philippu, et al.,Behavioural Brain Research, 2001, 124, 151-159.
Bacciottini, et al.,Behavioural Brain Research, 2001, 124, 183-194.
Kim, et al.,Neuroscience Letters, 2002, 321, 169-172.
Leurs, et al.,TiPS, May 1998, vol. 19, 177-183.
Tozer, et al.,Exp. Opin. Ther. Patents, 2000, 10, 1045-1055.
Passani, et al.,Neuroscience and Biobehavioral Reviews, 2000, 24, 107-113.
Fox, et al.,Journal of Pharmacology and Experimental Therapeutics, 2003, 305, 897-908.
Ligneau, et al.,Journal of Pharmacology and Experimental Therapeutics, 1998, 287, 658-666.
Monti, et al.,European Journal of Pharmacology, 1991, 205, 283-287.
Stark, et al.,Drugs of the Future, 1996, 21, 507-520.
Howard,Exp. Opin. Ther. Patents, 2000, 10, 1549-1559.
Itoh, et al.,Biol. Psychiatry, 1999, 45, 475-481.
Masaki, et al.,Diabetes, 2001, 50, 376-384.
Masaki, et al.,Endocrinology, 2003, 144, 2741-2748.
Rouleau, et al.,Journal of Pharmacology and Experimental Therapeutics, 1997, 281, 1085-1094.
A-431404,Pharmaproject, Preclinical Trial, 2005.
3H-A-349821,Pharmaproject, Preclinical Trial, 2005.
Perry, et al.,The Lancet, 1977, 189.
Perry, et al.,British Medical Journal, 1978, 2, 1457-1459.
Blandina, et al.,British Journal of Pharmacology, 1996, 119, 1656-1664.
Cecchi, et al.,European Journal of Neuroscience, 2001, 13, 68-78.
Philippu, et al.,Drug News Perspect, 2001, 14, 523-529.
Perio, et al.,Psychopharmacology, 1989, 97, 262-268.
Morris, et al.,Nature, 1982, 297, 681-683.
Miyazaki, et al.,Life Sciences, 1995, 57, 2137-2144.
Meguro,Pharmacology Biochemistry and Behavior, 1995, 50, 321-325.
Prast, et al.,Brain Research, 1996, 734, 316-318.
Ghi, et al.,Prog. Neuro-Psychopharmacol & Biol. Psychiat., 1998, 22, 387-395.
Flood, et al.,Psychopharmacology, 1998, 140, 279-284.

Affiliated with

Also associated with

Rating

Octahydro-2H-pyrido[1,2-a]pyrazine compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Octahydro-2H-pyrido[1,2-a]pyrazine compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Octahydro-2H-pyrido[1,2-a]pyrazine compounds will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3552033