Oct3/4, Klf4, c-Myc and Sox2 produce induced pluripotent...

Details Oct3/4, Klf4, c-Myc and Sox2 produce induced pluripotent... Oct3/4, Klf4, c-Myc and Sox2 produce induced pluripotent...

2009-06-09

2011-11-15

Crouch, Deborah (Department: 1632)

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Method of regulating cell metabolism or physiology

C435S373000, C435S455000

Reexamination Certificate

active

08058065

ABSTRACT:
The present invention relates to a nuclear reprogramming factor having an action of reprogramming a differentiated somatic cell to derive an induced pluripotent stem (iPS) cell. The present invention also relates to the aforementioned iPS cells, methods of generating and maintaining iPS cells, and methods of using iPS cells, including screening and testing methods as well as methods of stem cell therapy. The present invention also relates to somatic cells derived by inducing differentiation of the aforementioned iPS cells.

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