Occular formulation comprising bromocriptine

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

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514913, A61K 3150, A61K 31495

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active

046543457

ABSTRACT:
Lyophylisates comprising bromocriptine or an acid addition salt thereof capable of reconstitution in an isotonic vehicle to provide a stable formulation for occular instillation, useful e.g. in the treatment of glaucoma. Typical lyophylisates in accordance with the invention comprise: a lyophylisable acid, e.g. methane sulfonic acid, an acid addition salt of bromocriptine with said acid, e.g. bromocriptine mesylate, benzalkonium chloride and a lyophylisate matrix material.

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The Theory and Practice of Industrial Pharmacy-2nd ed. pp. 521-524 (1976)--Lea & Febiger-Philadelphia, Pa.
Chem. Abst. 69:61505q (1968)--Marso.
Chem. Abst. 99:980p (1983)--Nistico et al.
Chem. Abst. 100:114,972g (1984)--Mekki et al.

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