Occlusive composition

Details Occlusive composition Occlusive composition

2002-04-12

2008-03-11

Hartley, Michael G. (Department: 1618)

Drug, bio-affecting and body treating compositions

Solid synthetic organic polymer as designated organic active...

Polymer from ethylenic monomers only

C424S422000

Reexamination Certificate

active

07341716

ABSTRACT:
The present invention provides an occlusive composition comprising: a) a poly(2-cyanoacrylate) monomer of the following formula (I):wherein n≧2 and R is an organic moiety; and b) a visualization agent. The present invention also provides a method for creating a solid mass in an ionic fluid-containing bodily cavity within a living organism, comprising delivering into the bodily cavity a clinically sufficient amount of an occlusive composition comprising a poly(2-cyanoacrylate) monomer of formula (I) and a visualization agent.

REFERENCES:
patent: 2721858 (1955-10-01), Joyner et al.
patent: 3142698 (1964-07-01), Halpern et al.
patent: 3254111 (1966-05-01), Hawkings et al.
patent: 3355482 (1967-11-01), Coover, Jr. et al.
patent: 3463804 (1969-08-01), Ray et al.
patent: 3654340 (1972-04-01), Banitt
patent: 3701771 (1972-10-01), Almen et al.
patent: 3940362 (1976-02-01), Overhults
patent: 3975422 (1976-08-01), Buck
patent: 4012402 (1977-03-01), Buck
patent: 4364921 (1982-12-01), Speck et al.
patent: 4847065 (1989-07-01), Akimova et al.
patent: 5140084 (1992-08-01), Mikuni et al.
patent: 5202352 (1993-04-01), Okada et al.
patent: 5359101 (1994-10-01), Woods et al.
patent: 5504252 (1996-04-01), Klemarczyk
patent: 5624669 (1997-04-01), Leung et al.
patent: 5695480 (1997-12-01), Evans et al.
patent: 5702361 (1997-12-01), Evans et al.
patent: 5795331 (1998-08-01), Cragg et al.
patent: 5851508 (1998-12-01), Greff et al.
patent: 5882334 (1999-03-01), Sepetka et al.
patent: 5925683 (1999-07-01), Park
patent: 6037366 (2000-03-01), Krall et al.
patent: 6051607 (2000-04-01), Greff
patent: 6096848 (2000-08-01), Gololobov et al.
patent: 6143352 (2000-11-01), Clark et al.
patent: 6160025 (2000-12-01), Slaikeu et al.
patent: 6174919 (2001-01-01), Hickey
patent: 6538026 (2003-03-01), Krall et al.
patent: 1197464 (1989-09-01), None
patent: 7033726 (1995-02-01), None
patent: WO 94/15907 (1994-07-01), None
patent: WO 96/39469 (1996-12-01), None
patent: WO 99/03404 (1999-01-01), None
patent: WO 00/44287 (2000-08-01), None
Tseng et al., “Modified ethoxyethyl cyanoacrylate for therapeutic embolization of arteriovenous malformation,” J. Bomed. Mater. Research. 24, 65-78 (1990).
Biochemistry: The Chemical Reactions of Living Cells by David E. Metzler, p. 3.
Handbook of chemistry and Physics, 57thedition, 1976-1977, p. F-112.
Vinters et al., “The Histotoxicity of Cyanoacrylate: A Selective Review,”Neuroradiology27, 279-91 (1985).
Oowaki et al., “Non-adhesive cyanoacrylate as an embolic material for endovascular neurosurgery,”Biomaterials21(10), 1039-46 (2000).
Kennedy, J.P. et al., “Macromers by carbocationic polymerization. X. Synthesis, characterization, and polymerizability of cyanoacrylate-capped polyisobutylenes,”J. Macromol. Sci-Chem. A28(2), 209-24 (1991).
Tseng et al., “Modified ethoxyethyl cyyanoacrylate for therapeutic emobolization of arteriovenous malformation,”J. Biomed. Mater. Res. 24, 65-77 (1990).
Kerber et al., “Liquid acrylic adhesive agents in interventional neuroradiology,”Neurosurg. Clin. N. Am. 11(1), 85-99, viii-ix (1990).
Higashida R.T. et al., “Intracranial aneurysms. Evolution and future role of endovascular techniques.”Neurosurg. Clin. N. Am. 5(3), 413-25 (1994).
Tseng et al., “In vitro toxicity test of 2-cyanoacrylate polymers by cell culture method.”J. Biomed. Mater. Res. 24, 1355-67 (1990).
Brothers et al., “n-Butyl 2-cyanoacrylate—substitute for IBCA in interventional neuroradiology: Histopathologic and polymerization time studies.”Am. J. Neurorad. 10, 777-86 (1989).
Spiegel et al., “Adjusting the polymerization time of isobutyl-2-cyanoacrylate.”Am. J. Neurorad. 7, 109-112 (1986).
Klemarczyk P., “Adhesion studies of mixtures of ethyl cyanoacrylate with a difunctional cyanoacrylate monomer and with other electron-deficient olefins.”J. Adhesion69, 293-306 (1999).
Buck, C.J., “Unequivocal synthesis of bis(2-cyanoacrylate) monomers. I. Via anthracene adducts.”J. Polym. Sci.: Polym. Chem. Ed. 16, 2475-2507 (1978).

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