Obesity gene and use thereof

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

Reexamination Certificate

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C435S091100, C435S091200, C536S023100

Reexamination Certificate

active

08034564

ABSTRACT:
The present invention relates generally to the field of human genetics. Specifically, the present invention relates to methods and materials used to isolate and detect a human obesity and diabetes predisposing gene, specifically the TBC1D1 gene, some mutant alleles of which cause susceptibility to obesity and/or diabetes. More specifically, the invention relates to germline mutations in the TBC1D1 gene and their use in the diagnosis of predisposition to obesity and diabetes. Finally, the invention relates to the screening of the TBC1D1 gene for mutations/alterations, which are useful for diagnosing the predisposition to obesity.

REFERENCES:
patent: 5700927 (1997-12-01), Zon et al.
patent: 6825004 (2004-11-01), Blumenfeld et al.
Genbank Accession No. NM—015173; Sep. 2005.
Genbank Accession No. NM—015173; Oct. 2002.
Genbank Accession No. NP—055988; Sep. 2005.
Genbank Accession No. NP—055988; Oct. 2005.
Richardson et al., “Molecular cloning of a cDNA with a novel domain present in thetre-2 oncogene and the yeast cell cycle regulatorsBUB2andcdc16”, Oncogene, Sep. 1995, 11(6):1139-1148.
White et al., “The gene encoding TBC1D1 with homology to the tre-2/USP6 oncogene, BUB2, and cdc16 maps to mouse chromosome 5 and human chromosome 4”,Cytogenetics and Cell Genetics, 2000, 89(3-4):272-275.

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