Obesity gene

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C536S023100, C536S023400, C536S024100, C536S024330, C435S320100, C435S325000

Reexamination Certificate

active

06998472

ABSTRACT:
The invention describes a previously unknown gene, termed 5′OT-EST, which is responsible for inducing an obesity and/or infertility phenotype in transgenic animals, and transgenic animals comprising mutants of 5′OT-EST which are useful for assaying compounds for the treatment of obesity and/or infertility.

REFERENCES:
E Mohr et al., Biochimie, “A single rat genomic DNA fragment encodes both the oxytocin and vasopressin genes separated by 11 kilobases and oriented in opposite transcriptional directions,” 1988, 70:649-654.
E Schmitz et al., DNA and Cell Biology, “Rat Vasopressin and Oxytocin Genes are Linked by a long interspersed Repeated DNA element(LINE):Sequence and Transcriptional Analysis of LINE,” 1991, vol. 10, No. 2,pp. 81-91.
GenBank Accession No. H31114.
GenBank Accession No. AA955566.
GenBank Accession No. AA421393.
GenBank Accession No. AA505752.
GenBank Accession No. AA421310.
GenBank Accession No. AA242211.
GenBank Accession No. AA245389.
GenBank Accession No. AA104183.
GenBank Accession No. AA850004.
GenBank Accession No. H31115.
Al-Shawi, Raya, et al. (1990). Expression of a Foreign Gene in a Line of Transgenic Mice Is Modulated by a Chromosomal Position Effect.Molecular and Cellular Biology.10, 1192-98.
Ang, H-L, et al. (1994). Over-expression of oxytocin in the testes of a transgenic mouse model.Journal of Endocrinology.140, 53-62.
Ang, Hwee-Luan, et al. (1991). Testicular Oxytocin Gene Expression in Seminiferous Tubules of Cattle and Transgenic Mice.Endocrinology.128, 2110-17.
Banerjee, Shilpi A., et al. (1994). DNA regulatory sequences of the rat tyrosine hydroxylase gene direct correct catecholaminergic cell-type specificity of a human growth hormone reporter in the CNS of transgenic mice causing a dwarf phenotype.Molecular Brain Research.24, 89-106.
Bartke, A., et al (1988). Infertility in Transgenic Female Mice with Human Growth Hormone Expression: Evidence for Luteal Failure.The Journal of Experimental Zoology.248, 121-124.
Bartke, A., et al. (1992). Effects of expression of human or bovine growth hormone genes on sperm production and male reproductive performance in four lines of transgenic mice.Journal of Reproduction&Fertility. Abstract Series/Society for the Study of Fertility.95, 109-118.
Bonifer, Constanze, et al. (1990). Tissue specific and position independent expression of the complete gene domain for chickent lysozyme in transgenic mice.European Molecular Biology Organsation Journal.9, 2843-48.
Boss, Olivier, et al. (1997). Uncoupling protein-3: a new member of the mitochondrial carrier family with tissue-specific expression.Febs Letters.408, 39-42.
Bowie, Kahle, E., et al. (1997). The Rat Corpulent (cp) Mutation Maps to the Same Interval on (Pgm1-Glut1) Rat Chromosome 5 as the Fatty (fa) Mutation.Obesity Research.5, 142-5.
Bucchini, D., et al. (1986). Pancreatic expression of human insulin gen in transgenic mice.National Academy of Sciences.83, 2511-15.
Chen, Hong, et al., (1996). Evidence that the Diabetes Gene Encodes the Leptin Receptor: Indentification of a Mutation in the Leptin Receptor Gene in db/db Mice.Cell.84, 491-495.
Coleman, D.L. and Eicher, E. M. (1990). Fat (fat) and Tubby (tub): Two Autosomal Recessive Mutations Causing Obesity Syndromes in the Mouse.Journal of Hereditary.81, 424-27.
Comuzzie, Anthongy G. and Allison, David B. (1998). The Search for Human Obesity Genes.Science.280, 1374-77.
Cool, David R., et al. (1997). Carboxypeptidase E is a Regulated Secretory Pathway Sorting Receptor: Genetic Obliteration Leads to Endocrine Disorders in CpefatMice.Cell.88, 73-83.
Fan, Wei, et al. (1997). Role of melanocortinergic neurons in feeding and the agouti obesity syndrome.Nature.385, 165-8.
Flavell, D.M., et al. (1996). Dominant dwarfism in transgenic rats by targeting human growth hormone (GH) expression to hypothalamic GH-releasing factor neurons.European Molecular Biology Organisation Journaal.15, 3871-79.
Fujiwara, Y., et al. (1997). Position-Independent and High-Level Expression of Human α-Lactalbumin in the Milk of Transgenic Rats Carrying a 210-kb YAC DNA.Molecular Reproduction and Development.47, 157-163.
Good, Deborah J., et al. (1997). Hypogonadism and obesity in mice with a targeted deletion of the Nhlh2 gene.Nature Genetics.15, 397-401.
Graham, Melissa (1997). Overexpression of Agrt leads to obesity in transgenic mice.Nature Genetics.17, 273-274.
Grant, Frederick D., et al. (1993). Expression of the Rat Arginine Vasopressin Gene in Transgenic Mice.Molecular Endocrinology.7, 659-67.
Grosveld, Frank, et al. (1987). Position-Independent, High-Level Expression of the Human β-Globin Gene in Transgenic Mice.Cell.51, 975-85.
Habener, Joel F., et al. (1989). Metallothionein-Vasopressin Fusion Gene Expression in Trangenic Mice.Journal of Biological Chemistry.264, 18844-52.
Hammer, Robert E., et al. (1985). Production of transgenic rabbits, sheep and pigs by microinjection.Nature.315, 680-83.
Hanahan, Douglas, et al. (1983). Studies on Transformation ofEscherichia coliwith PlamidsJournal of Molecular Biology.166, 557-580.
Ho. Mei-Yin, et al. (1995). Bovine Oxytocin Transgenes in Mice.Journal of Biological Chemistry.270, 27199-05.
Hollingshead, Philiip G., et al. (1989). A Dominant Phenocopy of Hypopituitarism in Transgenic Mice Resulting from Central Nervous System Synthesis of Human Growth Hormone.Endocrinology.125, 1556-64.
Huber, Matthias, et al. (1994) Chromosomal position effects in chicken lysozyme gene transgenic mice are correlated with supression of Dnase I hypersensitive site formation.Nucleic Acids Research.22, 4195-4201.
Huszar, Dennis, et al. (1997). Targeted Disruption of the Melanocortin-4 Receptor Results in Obesity in Mice.Cell Press.88, 131-141.
Jamal, Zahirali, et al. (1997). Phosphatidate phosphohydrolases in liver, heart and adipose tissue of the JCF:LA corpulent rat and the lean genotypes: implications for glycerolipid synthesis and signal transduction.International Journal of Obesity.116, 789-99.
Jones, Beverly K., et al. (1995). The Human Growth Hormone Gene is Regulated by a Multicomponent Locus Control Region.Molecular and Cellular Biology.15, 7010-21.
Klebig, M.L., et al. (1995) Ectopic expression of the agouti gene in transgenic mice causes obesity, features of type II diabetes, and yellow fur.National Academy of Sciences.92, 4728-32.
Kristensen, Peter, et al. (1998). Hypothalamic CART is a new anorectic peptide regulated by leptin.Nature.393, 72-76.
Kleyn, Patrick W., et al. (1996). Identification and Characterization of the Mouse Obesity Gene tubby: A Member of Novel Gene Family.Cell Press.85, 281-90.
Lacy, Elizabeth, et al. (1983). A Foreign β-Globin Gene in Transgenic Mice: Intergration at Abnormal Chromosomal Positions and Expression in Inappropriate Tissues.Cell.34, 343-358.
Lecea, L. De, et al (1998). The hyprocretins: Hypothalamus-specific peptides with neuroexcitatory activity.National Academy of Sciences.95, 322-327.
Lee, G.H., et al. (1997). Leptin receptor mutations in 129 db3J/db3Jmice and NIH facp/facprats.Mammalian Genome.8, 445-7.
McGrane, Mary M., et al. (1988). Tissue-specific Expression and Dietary Regulation of a Chimeric Phosphoenolypruvate Carboxykinase/Bovine Growth Hormone Gene in Transgenic Mice.Journal of Biological Chemistry.263, 11443-51.
Miller, Miles, W., et al. (1993). Cloning of the mouse agouti gene predicts a secreted protein ubiquitously expressed in mice carrying the lethal yellow mutation.Genes&Development.7, 454-467.
Millet, Laurence, et al. (1997). Increased Uncoupling protein-2 and -3 mRNA Expression during Fasting in Obese and Lean Humans.Journal of Clinical Investigations.100, 2665-70.
Moon Byoung Chon and Jeffrey M. Friedman (1997). The Molecular Basis of the Obese Mutation in ob2JMice.GENOMICS.42, 152-6.
Morello, D., et al. (1986). Studies on the expression of an H-2K/human growth hormone fusion gene in giant transgenic mice.European Molecular Biology Organisation Journal.5, 11877-83.
Murphy D. and Ho, M. Y. (1995). Oxytocin Transgenic Mice.Oxytocin.395, 67-78.
Naggert, Jürgen K., et

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Obesity gene does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Obesity gene, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Obesity gene will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3688742

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.