OAT5 molecules and uses therefor

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

Reexamination Certificate

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C435S325000, C435S252300, C435S254110, C435S254200, C435S320100, C536S023500

Reexamination Certificate

active

06972187

ABSTRACT:
The invention provides isolated nucleic acids molecules, designated OAT5 nucleic acid molecules, which encode organic anion transporters. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing OAT5 nucleic acid molecules, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a OAT5 gene has been introduced or disrupted. The invention still further provides isolated OAT5 polypeptides, fusion polypeptides, antigenic peptides and anti-OAT5 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.

REFERENCES:
patent: 6680379 (2004-01-01), Sun
patent: WO 98/45437 (1998-10-01), None
Sweet et al., The organic anion transporter family: from physiology to ontogeny and the clinic. Am. J. Physiol. Renal Physiol. 281: F197-F205, 2001.
Fu-zhang, W., Cloning and characterization of two novel OATP genes on human 5q21.1. GenBank Database, Accession No. AY273896, Dec. 1, 2003.
DGene Accession No. AAV87708; New polynucleotides encoding human secreted proteins—derived from e.g. human blood, kidney, foetal lung, placenta, testes, brain, ovary, pituitary, retina and colon cDNA libraries (Feb. 12, 1999).
EST database Accession No. AA619778; SW:PGT_RAT Q00910 Prostaglandin Transporter (Oct. 9, 1997).
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Ullrich, K.J. “Renal Transporters for Organic Anions and Organic Cations, Structural Requirements for Substrates”The Journal of Membrane BiologyJul. 15, 1997, vol. 158, pp. 95-107.
Ullrich K.J. et al. “Renal Transport Mechanisms for Xenobiotics: Chemicals and Drugs”The Clinical InvestigatorOct. 1993, vol. 71, pp. 843-848.

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