Oasis gene-deficient mouse

Details Oasis gene-deficient mouse Oasis gene-deficient mouse

2006-09-25

2010-12-07

Sajjadi, Fereydoun G (Department: 1617)

Multicellular living organisms and unmodified parts thereof and

Nonhuman animal

Transgenic nonhuman animal

C800S008000, C800S009000

Reexamination Certificate

active

07847148

ABSTRACT:
A mouse that is deficient in the function of the gene for OASIS, and a method for screening for, or evaluating a pharmacological efficacy of, therapeutic agents for osteoporosis using the mouse.

REFERENCES:
patent: 2005-052016 (2005-03-01), None
Honma et al. Mol. Brain Res. 69:93-103; 1999.
Yutaka Honma et al., “Identification of a novel gene, OASIS, which encodes for a putative CREB/ATF family transcription factor in the long-term cultured astrocytes andgliotic tissue”, Molecular Brain Research 69 (1999) 93-103.
Tomohiko Murakami et al., “Cleavage of the membrane-bound transcription factor OASIS in response to endoplasmic reticulum stress”, Journal of Neurochemistry, 2006, 96, 1090-1100.
Kazunori Imaizumi et al., “Saiboshu Tokuiteki Shohotai Stress Oto-astrocytes ni Hakken suru Shinki Shohotai Stress Sensor OASIS”, Folia Pharmacol. Jpn. 2004, vol. 124, pp. 383 to 390.
Supplementary European Search Report for EP 06 81 0983 dated Jan. 12, 2010.
T. Nikaido et al., “Expression of the novel transcription factor OASIS, which belongs to the CREB/ATF family, in mouse embryo with special reference to bone development”, Histochemistry and Cell Biology, (2001) 116:141-148.

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