O-thiocarbamoyl-aminoalkanol compounds, their pharmaceutically u

Details O-thiocarbamoyl-aminoalkanol compounds, their pharmaceutically u O-thiocarbamoyl-aminoalkanol compounds, their pharmaceutically u

1998-01-13

1999-08-10

Kumar, Shailendra

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

N-c doai

514489, 514423, 514255, 5142375, 544358, 544389, 544159, 544160, 548331, 558234, A61K 3127, C07C33304

Patent

active

059359978

ABSTRACT:
The present invention relates to O-thiocarbamoyl-aminoalkanol compound represented by the following structural formula (VI), (VIII) and (IX) which are a racemic or enantiomerically enriched and pharmaceulically acceptable salts thereof to treat diseases of the central nervous system: ##STR1## wherein Ar is a phenyl group as described as follows: ##STR2## wherein R is a member selected from the group consisting of hydrogen, lower alkyl of 1 to 8 carbon atoms, halogen selected from F, Cl, Br, and I, alkoxy containing 1 to 3 carbon atoms, thioalkoxy containing 1 to 3 carbon atoms, nitro, hydroxy, or taifluorocarbon, and x is an integer from 1 to 3, with the proviso that R is the same or different when x is 2 or 3. R.sub.1 and R.sub.2 may be the same or different from each other and are independently selected from the group consisting of hydrogen, lower alkyl of 1 to 8 carbon atoms, aryl, 3 to 7-membered aliphatic cyclic compounds and R.sub.1 and R.sub.2, together with the adjoining N-atom, form a 5 to 7-membered cyclic compound which optionally comprises zero to one additional nitrogen atoms substituted with a member selected from the group consisting of hydrogen, alkyl and aryl groups, or zero to one oxygen atoms directly unconnected, R.sub.3 and R.sub.4 may be same or different from each other and are independently selected from the group consisting of hydrogen, lower alkyl of 1 to 8 carbon atoms, aryl, 3 to 7-membercd aliphatic cyclic compounds and R.sub.3 and R.sub.4, together with the adjoining N-atom, form a 5 to 7-membered cyclic compound which optidonally comprises zero to one additional nitrogen atoms substituted with a member selected from the group consisting of hydrogen, alkyl and aryl groups, or zero to one oxygen atoms directly unconnected, each of l, m and n is zero or 1, and the pharmaceutically acceptable salts thereof.

REFERENCES:
patent: 2901501 (1959-08-01), Wasson et al.
CA:55, 545e, 1961.

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