O.sup.6 -substituted guanine compounds and methods for depleting

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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544276, A61K 3152, C07D47300

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active

050914308

ABSTRACT:
O.sup.6 -substituted guanine compounds of the formula ##STR1## wherein R is a benzyl group or a substituted benzyl group, cause a depletion of O.sup.6 -alkylguanine-DNA alkyltransferase (AGT) activity in mammalian cells. These compounds may be administered to a host so as to reduce AGT levels in tumor cells of the host in order to increase host responsiveness to anti-neoplastic alkylating agents, including chloroethylating agents, such as chloroethylnitrosoureas, for chemotherapeutic treatment of a number of neoplasms.

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Moschel et al, "Substituent-Induced Effects on the Stability of Benzylated Guanosines . . . ", J. Org. Chem., 1984, 49, pp. 363-372.
Robins et al, "Purine Nucleosides . . . ", J. Org. Chem., vol. 34, No. 7, Jul. 1969, pp. 2160-2163.

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