Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1990-03-13
1992-02-25
Bond, Robert T.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
544276, A61K 3152, C07D47300
Patent
active
050914308
ABSTRACT:
O.sup.6 -substituted guanine compounds of the formula ##STR1## wherein R is a benzyl group or a substituted benzyl group, cause a depletion of O.sup.6 -alkylguanine-DNA alkyltransferase (AGT) activity in mammalian cells. These compounds may be administered to a host so as to reduce AGT levels in tumor cells of the host in order to increase host responsiveness to anti-neoplastic alkylating agents, including chloroethylating agents, such as chloroethylnitrosoureas, for chemotherapeutic treatment of a number of neoplasms.
REFERENCES:
patent: 4801710 (1989-01-01), MacCoss et al.
Dolan et al, Cancer Research, 46, pp. 4500-4505, (1986).
Dolan et al, Cancer Chemother. Pharmacol., 25, pp. 103-108, (1989).
Bowles et al, J. Med. Chem., 6, pp. 471-480 (1963).
Frihart et al, J. Am. Chem. Soc., 95, pp. 7174-7175 (1973).
Moschel et al, "Substituent-Induced Effects on the Stability of Benzylated Guanosines . . . ", J. Org. Chem., 1984, 49, pp. 363-372.
Robins et al, "Purine Nucleosides . . . ", J. Org. Chem., vol. 34, No. 7, Jul. 1969, pp. 2160-2163.
Dolan M. Eileen
Moschel Robert C.
Pegg Anthony E.
Bond Robert T.
Grumbling Matthew V.
The United States of America as represented by the Secretary of
LandOfFree
O.sup.6 -substituted guanine compounds and methods for depleting does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with O.sup.6 -substituted guanine compounds and methods for depleting, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and O.sup.6 -substituted guanine compounds and methods for depleting will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1893445