Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1991-12-12
1994-10-25
Shah, Mukund J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
544276, 514587, 514615, 514400, A61K 3132, C07D47318
Patent
active
053589521
ABSTRACT:
O.sup.6 -substituted guanine compounds of the formula ##STR1## wherein R is a benzyl group or a substituted benzyl group, cause a depletion of O.sup.6 -alkylguanine-DNA alkyltransferase (AGT) activity in mammalian cells. These compounds may be administered to a host so as to reduce AGT levels in tumor cells of the host in order to increase host responsiveness to anti-neoplastic alkylating agents, including chloroethylating agents, such as chloroethylnitrosoureas, for chemotherapeutic treatment of a number of neoplasms.
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Moschel et al., "Substituent-Induced effects on the stability of benzylated guanosines . . . ," J. Org. Chem., 1984, 49, pp. 363-372.
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Dolan M. Eileen
Moschel Robert C.
Pegg Anthony E.
Grumbling Matthew V.
Shah Mukund J.
The Penn State Research Foundation
The United States of America as represented by the Secretary of
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