O.sup.6 -substituted guanine compositions and methods for deplet

Details O.sup.6 -substituted guanine compositions and methods for deplet O.sup.6 -substituted guanine compositions and methods for deplet

1994-06-07

1997-11-25

Grumbling, Matthew V.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 13, 514 14, 514 15, 514 16, 514 18, 514 19, 514 20, 514262, 514 26, 514 27, 514 44, 514 45, 514 48, 514950, 514 81, 514245, 514183, 514589, 514256, 514771, 514417, 514414, 544276, 536 5, 536 173, 536 241, 530324, 530325, 530326, 530327, 530328, 530329, 530330, 530278, A61K 3154, A61K 31535, A61K 3152, A61K 3170, C07D40302, C07D40312, C07D47318, C07D41318

Patent

active

056913079

ABSTRACT:
Novel O.sup.6 -substituted guanine compounds and pharmaceutical compositions thereof are useful for effectively reducing O.sup.6 -alkylguanine-DNA alkyltransferase (AGT). The novel compounds are useful for treating tumors and when used with anti-neoplastic alkylating agents enhance the chemotherapeutic treatment of tumor cells in a host.

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