Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1990-11-21
1994-10-04
Bond, Robert T.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
514262, 544276, A61K 3170, A61K 3152, C07H 1702, C07D47318
Patent
active
053526694
ABSTRACT:
O.sup.6 -Benzylated guanine guanosine and 2'-deoxyguanosine compounds of the formula ##STR1## wherein Z is hydrogen, ##STR2## and R is a benzyl group or a substituted benzyl group, cause a depletion of O.sup.6 -alkylguanine-DNA alkyltransferase (AGT) activity in mammalian cells. These compounds may be administered to a host so as to reduce AGT levels in tumor cells of the host in order to increase host responsiveness to anti-neoplastic alkylating agents, including chloroethylating agents, such as chloroethylnitrosoureas, for chemotherapeutic treatment of a number of neoplasms.
REFERENCES:
patent: 4495190 (1985-01-01), Hagberg et al.
patent: 4801710 (1989-01-01), MacCoss et al.
Harrison's Principles of Internal Medicine, 10th Ed., 1983, pp. 751, 758, 766-775.
Chemical Abstract 104: 199, 241y (1986).
Chemical Abstract 107: 115, 902r (1987).
Chemical Abstract 101: 111, 324g (1984).
Himmelsbach et al., Tetrahedron (1984) 40(1) 59-72.
Chemical Abstract 99 22, 830s (1983).
Trichtinger et al., Tetrahedron Letter (1983) 24(7) 711-714.
Milne et al., J. Med. Chem. (1974) 17(3) 263-268.
Chem. Abstracts, vol. 104:179770s, Karkas et al., J. Med. Chem. 29(5)842-848 (1986).
Chem. Abstr. vol. 100:51936a, Moschel et al., J. Org. Chem. (1984) 49(2) 363-372.
Chem. Abstr. 99:71123x, Ford et al., J. Org. Chem. (1983) 48(13) 226-223.
Chemical Abstr. 71:39386w (1969).
Robins et al., J. Org. Chem. (1969) 34(7) 2160-2163.
Dolan et al, Cancer Research, 46, pp. 4500-4505, (1986).
Dolan et al, Cancer Chemother, Pharmacol., 25, pp. 103-108, (1989).
Bowles et al, J. Med. Chem., 6, pp. 471-480 (1963).
Frihart et al. J. Am. Chem. Soc., 95, pp. 7174-7175 (1973).
Pauley et al, Chem. Res. Toxicol., vol. 1, No. 6, pp. 391-397 (1988).
Dolan M. Eileen
Moschel Robert C.
Pegg Anthony E.
Bond Robert T.
Grumbling Matthew V.
The of the United States of America as represented by the Depart
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