O-sulphated bacterial polysaccharides and their use

Details O-sulphated bacterial polysaccharides and their use O-sulphated bacterial polysaccharides and their use

2005-05-31

2005-05-31

Peselev, Elli (Department: 1623)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C536S018700, C536S021000, C536S123100

Reexamination Certificate

active

06900311

ABSTRACT:
The present invention refers to the preparation of O-sulphated, N-sulphatated or N-acetylated derivatives, both epimerised or non epimerised, of K5, K4, and optionally defructosilated K4 and K40 polysaccharides and to their use as antiinflammatory agents in chronic and acute inflammations.

REFERENCES:
patent: 6288044 (2001-09-01), Zoppetti et al.
Leisten et al., “Interleukin-6 Serum Levels Correlate with Footpad Swelling in Adjuvant-Induced Arthritic Lewis Rats Treated with Cyclosporin A or Indomethacin”,Clinical Immunology and Immunopathology, vol. 56, pp. 108-115 (1990).
Magari et al., “Differential Effects of FK506 and Methotrexate on Inflammatory Cytokine Levels in Rat Adjuvant-Induced Arthritis”,The Journal of Rheumatology, vol. 30, pp. 2193-2200 (2003).
Lynn et al., “Adjunctive Therapy for Septic Shock: A Review of Experimental Approaches”,Clinical Infectious Diseases, vol. 20, pp. 143-158 (1995).
SJH Van Deventer (Academic Medical Center Review), “Tumor Necrosis Factor in Crohn's Disease”, Gut, vol. 40, pp. 443-448 (1997).
Stack et al., Randomized Controlled Trial of CDP571 Antibody to Tumour Necrosis Factor- in Crohn's Disease,The Lancet, vol. 349, pp. 521-524 (1997).
Ikonomidis et al., “Increased Proinflammatory Cytokines in Patients with Chronic Stable Angina and Their Reduction by Aspirin”,Circulation, pp. 793-798 (1999).
Rodriguez et al., “Structure and Serological Characteristics of the Capsular K4 Antigen ofEscherichia coli05: K4:H4, a fructose-containing polysaccharide with a Chondroitin Backbone”,Eur. J. Biochem.vol. 177, pp. 117-124 (1988).
Manzoni et al., “Production and Purification of An Extracellularly Produced K4 Polysaccharide FromEschericia coli”, Biotechnology Letters, vol. 18, No. 4, p. 383-386 (1966).
Ogamo et al., “Reactivity Toward Chemical Sulfation of Hydroxyl Groups of Heparin”,Carbohydrate Research, 193 165-172, (1989).
Dengler et al., “Structure of the Serine-Containing Capsular Poly-Saccharide K40 Antigen FromEscherichia coli08:K40:H9”,Carbohydrate Research, 150 233-240, 1986.
Rej et al., “Sulfation of Some Chemically-Modified heparins. Formation of a 3-sulfate analog of heparin”,Carbohydrate Research, 210, pp. 299-310 (1991).
Tyrrell et al., “Heparin in Inflammation: Potential Therapeutic Applications Beyond Anticoagulation”,Advances in Pharmacology, vol. 46, pp. 151-208, (1999).
Gaffney et al., “Rheumatoid Arthritis and Heparin”,British Journal of Rheumatology, vol. 35, No. 8 p. 808, (Mar. 1996).
Salas et al., “Heparin attenuates TNF-α Induced Inflammatory Response through a CD1 1b Dependent Mechanism”,Gut, vol. 47, pp. 88-96, (2000).
Lever et al., “The effects of heparin and related molecules upon the adhesion of human polymorphonuclear leucocytes to vascular endothelium in vitro”,British Journal of Pharmacology, 129, pp. 533-540, (2000).
Attanasio et al., “Cytokine Gene Expression in Human LPS- and IFNγ-Stimulated Mononuclear Cells is Inhibited by Heparin”,Thromb Haemost, vol. 79, pp. 959-962, (1998).
Pepe et al., “Tissue Factor and Plasminogen Activator Inhibitor Type 2 Expression in Human Stimulated Monocytes is Inhibited by Heparin”,Seminars in Thrombosis and Hemostasis, vol. 23, No. 2, (1997).

Affiliated with

Also associated with

Rating

O-sulphated bacterial polysaccharides and their use does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with O-sulphated bacterial polysaccharides and their use, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and O-sulphated bacterial polysaccharides and their use will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3437438