O-sulfate derivatives of avermectins and milbemycins having impr

Details O-sulfate derivatives of avermectins and milbemycins having impr O-sulfate derivatives of avermectins and milbemycins having impr

1985-08-01

1986-11-11

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 71, 514450, 549264, A61K 3170, A61K 31365, C07H 1708, C07D49322

Patent

active

046223134

ABSTRACT:
There are disclosed novel O-sulfate derivatives of avermectin and milbemycin. The avermectin and milbemycin O-sulfate derivatives have improved water solubility compared to the parent avermectin and milbemycin compounds and have utility as anti-parasitic agents and as potent insecticides against agricultural pests.

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patent: 4470976 (1984-09-01), Miner et al.
Nishino et al., Biochemistry, 18 4340-4347 (1979).
Koster et al., JACS 105 3743-3745 (1983).
Galardy et al., Biochem. J., 226 447-454 (1985).

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