O-substituted hydroxyaryl derivatives

Details O-substituted hydroxyaryl derivatives O-substituted hydroxyaryl derivatives

2003-06-05

2009-12-01

Stockton, Laura L. (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C514S423000, C514S330000, C514S255010, C514S237500, C544S172000, C544S389000, C546S239000

Reexamination Certificate

active

07626042

ABSTRACT:
A medicament having inhibitory activity against NF-κB activation which comprises as an active ingredient a substance selected from the group consisting of a compound represented by the following general formula (I) and a pharmacologically acceptable salt thereof, and a hydrate thereof and a solvate thereof:wherein X represents a connecting group whose number of atoms in a main chain is 2 to 5 (said connecting group may be substituted),“A” represents an acyl group which may be substituted, (provided that unsubstituted acetyl group and unsubstituted acryloyl group are excluded,) or a C1to C6alkyl group which may be substituted, or A may bind to connecting group X to form a cyclic structure which may be substituted,“E” represents an aryl group which may be substituted or a heteroaryl group which may be substituted,ring Z represents an arene which may have one or more substituents in addition to the group represented by formula —O-A wherein A has the same meaning as that defined above and the group represented by formula —X-E wherein each of X and E has the same meaning as that defined above, or a heteroarene which may have one or more substituents in addition to the group represented by formula —O-A wherein A has the same meaning as that defined above and the group represented by formula —X-E wherein each of X and E has the same meaning as that defined above.

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