O-Substituted 7.beta.-amino-3-cephem-3-ol-4-carboxylic acid comp

Details O-Substituted 7.beta.-amino-3-cephem-3-ol-4-carboxylic acid comp O-Substituted 7.beta.-amino-3-cephem-3-ol-4-carboxylic acid comp

1976-02-13

1978-02-14

Rizzo, Nicholas S.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

544 16, A61K 3138, C07D50116, C07D50160

Patent

active

040739023

ABSTRACT:
The invention relates to O-substituted 7.beta.-amino-3-cephem-3-ol-4-carboxylic acid compounds of the formula ##STR1## wherein X represents amino or substituted amino, R.sub.2 represents hydroxyl or a group R.sub.2.sup.A which together with the carbonyl grouping --C(.dbd.O)-- forms a protected carboxyl group and R.sub.3 represents an optionally substituted hydrocarbon radical or an acyl group, and to 1-oxides of 3-cephem compounds of the formula IA, and also to the corresponding 2-cephem compounds of the formula ##STR2## wherein X, R.sub.2 and R.sub.3 have the abovementioned meanings, or salts of such compounds with salt-forming groups. 3-Cephem compounds of the formula IA, particularly those, in which X represents an amino group, R.sub.2 is hydroxy and R.sub.3 is lower alkyl exhibit pronounced antimicrobial effects, the others, and particularly the 1-oxides of these 3-cephem compounds and the corresponding 2-cephem compounds are useful as intermediates.

REFERENCES:
patent: 3704297 (1972-11-01), Dvonch et al.
patent: 3741962 (1973-06-01), Breuer
patent: 3846417 (1974-11-01), Atwal et al.
patent: 3907786 (1975-09-01), Naito et al.
patent: 3917588 (1975-11-01), Chauvette

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