O- or S-substituted dihydronaphthalene derivatives having retino

Details O- or S-substituted dihydronaphthalene derivatives having retino O- or S-substituted dihydronaphthalene derivatives having retino

1996-06-21

1998-09-15

Shaver, Paul F.

Organic compounds -- part of the class 532-570 series

Organic compounds

Silicon containing

544336, 544335, 548110, 548146, 548201, 548215, 5483351, 560 10, 560 56, 560102, 560100, 560 80, 560107, 560128, 560235, 560510, 558426, 558 61, 558 62, 556413, 556428, 546 14, 546337, 546339, 546322, 546344, 546342, 546348, 5462817, 5462824, 5462837, 549214, 549 29, 549 71, 549429, 549489, 544229, 544224, 544238, 544242, 562426, 562429, 562460, 562490, 562492, 562466, 534558, 534560, 534564, 568 27, 568 28, 568 31, C07F 704, C07F 708, C07F 710

Patent

active

058081240

ABSTRACT:
Compounds of the formula ##STR1## where the symbols have the meaning described in the application, have retinoid-like or retinoid antagonist-like biological activity.

REFERENCES:
patent: 4096341 (1978-06-01), Frazer
patent: 4326055 (1982-04-01), Loeliger
patent: 4391731 (1983-07-01), Boller et al.
patent: 4695649 (1987-09-01), Magami et al.
patent: 4723028 (1988-02-01), Shudo
patent: 4739098 (1988-04-01), Chandraratna
patent: 4740519 (1988-04-01), Shroot et al.
patent: 4810804 (1989-03-01), Chandraratna
patent: 4826969 (1989-05-01), Maignan et al.
patent: 4826984 (1989-05-01), Berlin et al.
patent: 4855320 (1989-08-01), Chatterjee et al.
patent: 4895868 (1990-01-01), Chandraratna
patent: 4927947 (1990-05-01), Chandraratna
patent: 4980369 (1990-12-01), Chandraratna
patent: 4992468 (1991-02-01), Chandraratna
patent: 5006550 (1991-04-01), Chandraratna
patent: 5013744 (1991-05-01), Chandraratna
patent: 5015658 (1991-05-01), Chandraratna
patent: 5023341 (1991-06-01), Chandraratna
patent: 5037825 (1991-08-01), Klaus et al.
patent: 5045551 (1991-09-01), Chandraratna
patent: 5053523 (1991-10-01), Chandraratna
patent: 5068252 (1991-11-01), Chandraratna
patent: 5089509 (1992-02-01), Chandraratna
patent: 5130335 (1992-07-01), Chandraratna
patent: 5134159 (1992-07-01), Chandraratna
patent: 5162546 (1992-11-01), Chandraratna
patent: 5175185 (1992-12-01), Chandraratna
patent: 5183827 (1993-02-01), Chandraratna
patent: 5202471 (1993-04-01), Chandraratna
patent: 5231113 (1993-07-01), Chandraratna
patent: 5234926 (1993-08-01), Chandraratna
patent: 5248777 (1993-09-01), Chandraratna
patent: 5264456 (1993-11-01), Chandraratna
patent: 5264578 (1993-11-01), Chandraratna
patent: 5272156 (1993-12-01), Chandraratna
patent: 5278318 (1994-01-01), Chandraratna
patent: 5324744 (1994-06-01), Chandraratna
patent: 5324840 (1994-06-01), Chandraratna
patent: 5326898 (1994-07-01), Chandraratna
patent: 5344959 (1994-09-01), Chandraratna
patent: 5346895 (1994-09-01), Chandraratna
patent: 5346915 (1994-09-01), Chandraratna
patent: 5348972 (1994-09-01), Chandraratna
patent: 5348975 (1994-09-01), Chandraratna
patent: 5349105 (1994-09-01), Chandraratna
patent: 5354752 (1994-10-01), Chandraratna
patent: 5380877 (1995-01-01), Chandraratna
patent: 5391753 (1995-02-01), Chandraratna
patent: 5399561 (1995-03-01), Chandraratna
patent: 5399586 (1995-03-01), Davies et al.
patent: 5407937 (1995-04-01), Chandraratna
patent: 5414007 (1995-05-01), Chandraratna
patent: 5426118 (1995-06-01), Chandraratna
patent: 5434173 (1995-07-01), Chandraratna
patent: 5451605 (1995-09-01), Chandraratna et al.
patent: 5455265 (1995-10-01), Chandraratna
patent: 5468879 (1995-11-01), Chandraratna
patent: 5470999 (1995-11-01), Chandraratna
patent: 5475022 (1995-12-01), Chandraratna
patent: 5475113 (1995-12-01), Chandraratna
patent: 5489584 (1996-02-01), Vuligonda et al.
patent: 5498755 (1996-03-01), Chandraratna et al.
patent: 5498795 (1996-03-01), Song et al.
patent: 5514825 (1996-05-01), Vuligonda et al.
patent: 5516904 (1996-05-01), Chandraratna
patent: 5534516 (1996-07-01), Chandraratna
patent: 5534641 (1996-07-01), Song et al.
patent: 5543534 (1996-08-01), Vuligonda et al.
A General Synthesis of Terminal and Internal Arylalkynes by the Palladium-Catalyzed Reaction of Alkynylzinc Reagents with Aryl Halides by Anthony O. King and Ei-ichi, J. Org. Chem., (1978) 43/2: p. 358.
Conversion of Methyl Ketones into Terminal Acetylenes and (E)-Tri-substituted Olefins of Terpenoid Origin by Ei-ichi, et al., J. Org. Chem., (1980) 45/12: p. 2526.
Sporn et al. in J. Amer. Acad. Derm . . . , (1986) 15:756-764.
"A Convenient Synthesis of Ethynylarenes and Diethynylarenes" by S. Takahashi et al. Synthesis (1980) pp. 627-630.
Shudo et al. in Chem. Phar. Bull., (1985) 33:404-407.
Kagechika et al. in J. Med. Chem., (1988) 31:2182-2192.
Chemistry and Biology of Synthetic Retinoids by Marcia I. Dawson and William H. Okamura, published by CRC Press Inc., 1990, pp. 334-335, 354.
Synthesis of 2,2'-Diacyl-1,1'-Biaryls. Regiocontrolled Protection of . . . by Mervic, et al, J. Org. Chem.,(1980) No. 45, pp. 4720-4725.
A Dopamine Receptor Model and Its Application in the Design of a New Class American Chemical Societe, (1981) 24/9:1026-1031.
6.2.3 Conformational Restriction, Williams, et al., Drug Discovery and Development, The Humana Press, (1987) pp. 54-55.
V. Retinoid Structure-Biological Activity Relationships, Chemistry and Biology of Synthetic Retinoids, (1990) pp. 324-356.
Davis et al. J. Organometallic Chem (1990) 387:381-390.
"Effects of 13-Cis-Retinoic Acid, All Trans-Retinoic Acid, and Acitretin on the Proliferation, Lipid Synthesis and Keratin Expression of Cultured Human Sebocytes in Vitro" C.C. Zouboulis, The Journal of Investigative Dermatology, (1991) 96/5:792-797.
"Organ Maintenance of Human Sebaceous Glands: in Vitro Effects of 13-Cis Retinoic Acid and Testosterone", John Ridden, et al., Journal of Cell Science (1990) 95:125-136.
"Characterization of Human Sebaceous Cells in Vitro", Thomas I. Doran, et al. The Journal of Investigative Dermatology, (1991) 96/3:.
"Synthesis and Evaluation of Stilbene and Dihydrostilbene Derivatives as Potential Anticancer Agents That Inhibit Tubulin Polymerization" by Cushman, Mark et al. J. Med. Chem., (1991), 34:2579-2588.
"Synthesis and Evaluatinof New Pretoein Tyrosine Kinase Inhibitors. Part 1. Pyridine-Containing Stilbenes and Amides" by Cushman, Mark et al. Bioorganic & Medicinal Chemistry Letters, (1991) 1/4:211-214.
"Di- and Tri-methoxystyryl Derivatives of Heterocyclic Nitrogen Compounds" by Bahner,C. T. et al. Arzneim-Forsch,/Drug Res, (1981)31 (I), Nr. 3.
"Retinobenzoic acids. 3. Structure-Activity Relationships of Retinoidal Azobenzene-4-Carboxylic Acids and Stilbene-4- Carboxylic Acids" by H. Kagechika et al., Journal of Medicinal Chemistry, (1989), 32:1098-1108.
Eyrolles, L. et al. "Retinoid Antagonists: Molecular Design Based on the Ligand Superfamily Concept" Med. Chem. Res., (1992) 2:361-367.
Liu, S. S. et al. "Systemic Pharmacokinetics of Acetylenic Retinoids in Rats", Drug Metabolism and Disposition, (1990) 18/6: 1071-1077.

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