Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1977-12-16
1980-10-07
Lee, Mary C.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
2602452T, 424269, 424270, 424272, 424273R, 424274, 546272, C07D48704, A61K 3144, A61K 3140
Patent
active
042268702
ABSTRACT:
Disclosed are O-, N- and substituted carboxyl derivatives of the antibiotic thienamycin, which has the following structure: ##STR1## Such derivatives are useful as antibiotics. Also disclosed are processes for the preparation of such derivatives, pharmaceutical compositions comprising such derivatives, and methods of treatment comprising administering such derivatives and compositions when an antibiotic effect is indicated.
REFERENCES:
patent: 4162304 (1979-07-01), Box et al.
Hood et al.; The Jour. of Antibiotics, vol. XXXII, No. 4, pp. 295-304 (1979).
Brown et al.; J.C.S. Chem. Comm. (1977), pp. 523-525.
Corbett et al.; J.C.S. Chem. Comm. (1977), pp. 953-954.
Albers-Schonberg et al., J.A.C.S., vol. 100, pp. 6491-6499 (9-27-78).
Derwent Abstract/BE 839,324, 3/15/75.
Christensen Burton G.
Hannah John
Leanza William J.
Ratcliffe Ronald W.
Shih David H.
Arno James A.
Lee Mary C.
Levitt Julian S.
Merck & Co. , Inc.
Pfeiffer Hesna J.
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