O-heteroaryl, O-alkylheteroaryl, O-alkenylheteroaryl and O-alkyn

Details O-heteroaryl, O-alkylheteroaryl, O-alkenylheteroaryl and O-alkyn O-heteroaryl, O-alkylheteroaryl, O-alkenylheteroaryl and O-alkyn

1993-03-05

1994-05-10

Bond, Robert T.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

A61K 31395, C07D47118

Patent

active

053109015

ABSTRACT:
O-Heteroaryl, O-alkylheteroaryl, O-alkenylheteroaryl and O-alkynylheteroarylrapamycin derivatives of the general structural Formula I: ##STR1## have been prepared from suitable precursors by alkylation and/or arylation at C-42 and/or C-31. These compounds are useful in a mammalian host for the treatment of autoimmune diseases and diseases of inflammation, infectious diseases, the prevention of rejection of foreign organ transplants and the treatment of solid tumors.

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