Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1992-11-09
1993-11-02
Bond, Robert T.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
540456, A61K 31395, C07D49816
Patent
active
052583899
ABSTRACT:
O-Aryl, O-alkyl, O-alkenyl and O-alkynylrapamycin derivatives of the general structural Formula I: ##STR1## have been prepared from suitable precursors by alkylation and/or arylation at C-42 and/or C-31. These compounds are useful in a mammalian host for the treatment of autoimmune diseases and diseases of inflammation, infectious diseases, the prevention of rejection of foreign organ transplants and the treatment of solid tumors.
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Findlay, et al., Can. J. Chem., 58, 579-590 (1980).
Goulet Mark
Parsons William H.
Sinclair Peter J.
Wong Frederick
Wyvratt Matthew J.
Bond Robert T.
Caruso Charles M.
Merck & Co. , Inc.
Thies J. Eric
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