O-Aryl,O-alkyl,O-alkenyl and O-alkynylmacrolides having immunosu

Details O-Aryl,O-alkyl,O-alkenyl and O-alkynylmacrolides having immunosu O-Aryl,O-alkyl,O-alkenyl and O-alkynylmacrolides having immunosu

1993-10-04

1996-10-15

Bond, Robert T.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

C07D49116, A61K 31435

Patent

active

055655602

ABSTRACT:
O-Aryl, O-alkyl, O-alkenyl and O-alkynyl-macrolides of the general structural Formula I: ##STR1## have been prepared from suitable precursors by alkylation and/or arylation at C-3" and/or C-4" of the cyclohexyl ring. These macrolide immunosuppressants are useful in a mammalian host for the treatment of autoimmune diseases, infectious diseases and/or the prevention of rejection of foreign organ transplants and/or related afflictions, diseases and illnesses.

REFERENCES:
patent: 5250678 (1993-10-01), Goulet et al.
patent: 5349061 (1994-09-01), Sinclair et al.

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