Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1995-05-12
1996-07-02
Bond, Robert T.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
540456, 540452, 514411, A61K 31435, C07D49116
Patent
active
055322484
ABSTRACT:
O-Aryl, O-alkyl, O-alkenyl and O-alkynyl-macrolides of the general structural Formula I: ##STR1## have been prepared from suitable precursors by alkylation and/or arylation at C-3" and/or C-4" of the cyclohexyl ring. These macrolide immunosuppressants are useful in a mammalian host for the treatment of autoimmune diseases, infectious diseases and/or the prevention of rejection of foreign organ transplants and/or related afflictions, diseases and illnesses.
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Goulet Mark
Organ Helen M.
Parsons William H.
Sinclair Peter J.
Wong Frederick
Bond Robert T.
Merck & Co. , Inc.
Rose David L.
Yang Mollie M.
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