O-aminoalkylene (or aminoalkyleneoxy) phenylsulfone compounds ha

Details O-aminoalkylene (or aminoalkyleneoxy) phenylsulfone compounds ha O-aminoalkylene (or aminoalkyleneoxy) phenylsulfone compounds ha

1986-03-11

1988-03-29

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544375, 544392, 544394, 544399, 544403, 549 44, 549 46, 549 48, 564336, 564347, C07D29508, C07D33350

Patent

active

047345004

ABSTRACT:
A novel sulfone compound represented by the general formula (I) ##STR1## wherein R.sup.1 is cyclohexyl, phenyl; or a phenyl substituted with a group selected from nitro, C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 alkoxy and halogen; R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are respectively hydrogen, halogen, cyano or carbonyl, wherein R.sup.1 and R.sup.2 may form an o-phenylene or an o-phenylene substituted with at least one group selected from nitro C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 alkoxy and halogen; X is oxygen or methylene; Y is --(CH.sub.2).sub.n --, wherein n is an integer of 0, 5 or 6, or ##STR2## wherein m is an integer 1-3; R.sup.6 is hydrogen, C.sub.1 -C.sub.3 alkyl, .omega.-alkylaminoalkyl, wherein each alkyl has 1-3 carbon atoms, or .omega.-dialkylaminoalkyl, wherein each alkyl has 1-3 carbon atoms; R.sup.7 is hydrogen or C.sub.1 -C.sub.3 alkyl; and R.sup.6 and R.sup.7 may form a ring together with N, or ##STR3## wherein R.sup.8 is hydrogen, C.sub.1 -C.sub.3 hydroxyalkyl or phenyl; or a pharmaceutically acceptable salt thereof is disclosed. The compound has anti-ulcer effect.

REFERENCES:
patent: 3337628 (1967-08-01), Crowther et al.
patent: 4011217 (1977-03-01), Wasson
patent: 4201866 (1980-05-01), Hasegawa
Tobe et al., CA 105-226043q.
Kikumoto et al., CA 99-175384z.
March, Advanced Organic Chem., 2nd Edition, p. 492.
Kikumoto et al., J. Med. Chem., 1981, 24, pp. 145-148.

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