O-acyl-4-phenyl-cyclohexanols, their salts, medicaments containi

Details O-acyl-4-phenyl-cyclohexanols, their salts, medicaments containi O-acyl-4-phenyl-cyclohexanols, their salts, medicaments containi

1997-12-05

1999-10-05

Geist, Gary

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514212, 5142275, 514317, 514331, 5142378, 5142392, 514255, 514428, 548572, 540610, 546232, 546239, 544162, 544171, 544397, 544400, 549 14, A01N 4336, C07D20704, C07D21134, C07D21118

Patent

active

059625074

ABSTRACT:
Compounds that inhibit the enzyme 2,3-epoxysqualene-lanosterol-cyclase and cholesterol biosynthesis, of the formula I ##STR1## wherein n denotes the number 0 or 1, m denotes the number 1 or 2, p denotes the number 0 or 1, R.sup.1 and R.sup.2 each denote hydrogen, lower alkyl, alkenyl or alkynyl, which may optionally also be substituted, or together with the nitrogen atom between the denote 5- to 7-membered saturated, monocyclic or heterocyclic rings which may optionally also be interrupted by an oxygen or sulfur atom or by an imino group, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 denote hydrogen or lower alkyl, R.sup.5 additionally denotes lower alkoxy, R.sup.7 denotes hydrogen, cycloalkyl, phenyl or substituted phenyl, naphthyl, tetrahydronaphthyl, thienyl, furyl or pyridyl and A denotes a chemical bond or alkyl, alkenyl having up to 17 carbon atoms.

REFERENCES:
patent: 5455273 (1995-10-01), Maier et al.
Database CAPLUS on STN, Acc. No. 1995:905322, Borgulya et al., `Preparation and formulation of oxazolidin-2-ones as monoamine oxidase inhibitors.` abstract of EP 657440 A1.

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