Organic compounds -- part of the class 532-570 series – Organic compounds – Chalcogen in the nitrogen containing substituent
Patent
1976-08-19
1977-12-27
Myers, Jane S.
Organic compounds -- part of the class 532-570 series
Organic compounds
Chalcogen in the nitrogen containing substituent
C07D26534
Patent
active
040656233
ABSTRACT:
There is described the stereoselective total synthesis by a variety of routes of novel suitably substituted .DELTA..sup.2,3 -1, 4-morpholine-2-carboxylic acids possessing a fused .beta.-lactam ring in the 1,6-position and carrying a substituent cis to carbon 5 in the 7-position of the fused ring system represented by the general formula ##STR1## wherein Q is hydrogen, alkyl, aralkyl or --CH.sub.2 COOZ where Z is hydrogen or the residue of an ester group and X is amino, azido or acylamino. Also included in the invention are compounds of the above formula in which the carboxyl group at the 2-position is protected as by an easily cleavable ester group and salts of both the free acids and carboxyl-protected compounds. Those compounds in which X is acylamino and their physiologically hydrolyzed esters and pharmaceutically acceptable salts are potent antibacterial agents.
REFERENCES:
patent: 3835130 (1974-09-01), Woodward
Brunwin et al, J. Chem. Soc. Chem. Comm., 865-867 (1971).
Brunwin et al, J. Chem. Soc. Chem. Comm., 589-590 (1972).
Brunwin et al, J. Chem. Soc. (c) 3756-3762 (1971).
Wolfe et al, Can. J. Chem., 50, 2895-2905 (1972).
Kukolja, J.A.C.S. 93, 6267-6270 (1971).
Kukolja, J.A.C.S. 94, 7590-7593 (1972).
Lowe, et al, J. Chem. Soc. Perkins I, 1321-1328 (1973).
Luttringer et al, Tetrahedron Letters, 4163-4166 (1973).
Sheehan et al, J. Heterocycl. Chem., 5, 779-783 (1968).
Mukerjee et al, Synthesis, 327-346 (1973).
Belleau Bernard R.
Conway Terry T.
Doyle Terrence W.
Luh Bing Yu
Bristol-Myers Company
Morse David M.
Myers Jane S.
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