Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1993-08-12
1996-02-27
Sidberry, Hazel F.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
4241991, 4242041, 4242051, 4242181, 4242241, 4242271, 4242291, 4242301, 4242311, 4242321, 4242391, 4351723, 4353201, 530350, 530826, 514 2, A61K 39285, A61K 39295, C12N 701, C12N 1563
Patent
active
054948070
ABSTRACT:
What is described is a modified vector, such as a recombinant poxvirus, particularly recombinant vaccinia virus, having enhanced safety. The modified recombinant virus has nonessential virus-encoded genetic functions inactivated therein so that virus has attenuated virulence. In one embodiment, the genetic functions are inactivated by deleting an open reading frame encoding a virulence factor. In another embodiment, the genetic functions are inactivated by insertional inactivation of an open reading frame encoding a virulence factor. What is also described is a vaccine containing the modified recombinant virus having nonessential virus-encoded genetic functions inactivated therein so that the vaccine has an increased level of safety compared to known recombinant virus vaccines.
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Audonnet Jean-Christophe F.
Cox William I.
de Taisne Charles
Gettig Russell R.
Johnson Gerard P.
Sidberry Hazel F.
Tuscan Michael S.
Virogenetics Corporation
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