Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acid esters
Reexamination Certificate
2006-02-14
2006-02-14
Richter, Johann (Department: 1621)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carboxylic acid esters
C560S007000
Reexamination Certificate
active
06998501
ABSTRACT:
Triglycerides and cholesterol in the bloodstream are important factors in the development of cardiovascular disease. The present invention discloses a nutritional supplement comprising a sterol and an omega-3 fatty acid, or an ester thereof, for lowering cholesterol and triglyceride levels in the bloodstream of a subject. Preferably, the sterol and omega-3 fatty acid are together in the form of an ester.
REFERENCES:
patent: 4526902 (1985-07-01), Rubin
patent: 4588717 (1986-05-01), Mitchell
patent: 4681896 (1987-07-01), Horrobin
patent: 4879312 (1989-11-01), Kamarei et al.
patent: 5059622 (1991-10-01), Sears
patent: 5502045 (1996-03-01), Miettinen et al.
patent: 5593691 (1997-01-01), Eugster et al.
patent: 5604216 (1997-02-01), Horrobin
patent: 5770749 (1998-06-01), Kutney et al.
patent: 5892068 (1999-04-01), Higgins, III
patent: 5965449 (1999-10-01), Novak
patent: 6106886 (2000-08-01), van Amerongen et al.
patent: 6147236 (2000-11-01), Higgins, III
patent: 6162483 (2000-12-01), Wester
patent: 6184397 (2001-02-01), Roden et al.
patent: 6544973 (2003-04-01), Miettenen et al.
patent: 6589588 (2003-07-01), Wester et al.
patent: 2002/0016314 (2002-02-01), Schersl
patent: 2002/0055493 (2002-05-01), Burdick et al.
patent: 2002/0160990 (2002-10-01), Burdick et al.
patent: 2003/0054082 (2003-03-01), Koike et al.
patent: 2003/0198727 (2003-10-01), Koike et al.
patent: 2004/0052920 (2004-03-01), Koike et al.
patent: 2004/0062847 (2004-04-01), Koike et al.
patent: 2102112 (1992-11-01), None
patent: 1337548 (1995-11-01), None
patent: 0 594 612 (1991-05-01), None
patent: 0594612 (1991-05-01), None
patent: 9 703 329 (1997-02-01), None
patent: 9703329 (1997-02-01), None
patent: 0 897 970 (1999-02-01), None
patent: 0897970 (1999-02-01), None
patent: 897970 (1999-02-01), None
patent: 0982315 (2000-03-01), None
patent: 09826315 (2000-03-01), None
patent: 1004594 (2000-05-01), None
patent: WO9735594 (1987-10-01), None
patent: 9219640 (1992-11-01), None
patent: WO 92/19640 (1992-11-01), None
patent: WO9219640 (1992-11-01), None
patent: WO9806714 (1996-02-01), None
patent: WO 96/10033 (1996-04-01), None
patent: WO9510033 (1996-04-01), None
patent: WO9610033 (1996-04-01), None
patent: WO 96/38047 (1996-12-01), None
patent: WO 9638047 (1996-12-01), None
patent: WO 97/35594 (1997-10-01), None
patent: WO9735594 (1997-10-01), None
patent: WO 98/01759 (1998-01-01), None
patent: WO9801759 (1998-01-01), None
patent: 9806405 (1998-02-01), None
patent: WO 98/06714 (1998-02-01), None
patent: WO9806714 (1998-02-01), None
patent: WO 98/18429 (1998-05-01), None
patent: WO9818429 (1998-05-01), None
patent: WO 99/30569 (1999-06-01), None
patent: WO9930569 (1999-06-01), None
patent: 0004887 (2000-02-01), None
Lo et al., JAOCS, 60, 4, 1983.
Higashidate et al. (Journal of Chromatography (1990), 515, 295-303).
Mishkel et al. (Bailliere's Clinical Haematology, vol. 3, No. 3, Jul. 1990, pp 625-649).
Saynor et al., Changes in Blood Lipids and Fibrinogen with a Note on Safety in a Long Term Stdy on the Effects of n-3 Fatty Acids in Subjets Receiving Fish Oil Supplements and Followed for Seven Years, LIPIDS, vol. 27, No. 7, (1992), 533.
International Search Report.
Rompp Chemie Lexicon. (1995) Georg Thieme Verlag, Germany, Table 2 on p. 272 (English translation provided).
Nguyen, Tu T.; “The Cholestrol-Lowering Action of Plant Stanol Esters,” American Society for Nutritional Sciences, 1999.
Stalenhoef, Anton F.H., et al.; “The effect of concentrated n-3 fatty acids versus gemfibrozil on plasma lipoproteins, low density lipoprotein heterogeneity and ozidizability in patients with hypertrygliceridemia,” Atherosclerosis, vol. 153, 2000, pp. 129-138.
Mattson, Fred H., et al., “Optimizing the effect of plant sterols on cholesterol absorption in man1-3”, The American Journal of Clinical Nutrition (1982) 35:697-700.
Gould, R. Gordon, et al., “Absorbability of β-Sitosterol in Humans”, Metabolism, (1969) vol. 18, No. 8, pp. 652-662.
Lo, Y. C., et al., “Physical and Chemical Properties of Randomly Interesterified Blends of Soybean Oil and Tallow for Use as Margarine Oils1.2”, JAOCS, (1983) vol. 60, No. 4, pp. 815-818.
Sreenivasan, B., “Interesterification of Fats” JAOCS, (1978) vol. 55, pp. 796-805.
Chobanov, D., et al., “Alterations in Glyceride Composition During Interesterification of Mixtures of Sunflower Oil with Lard and Tallow”, JAOCS, (1977), vol. 54, pp. 47-50.
Saynor, Reginald, et al., “Changes in Blood Lipids and Fibrinogen with a Note on Safety in a Long Term Study on the Effects of n-3 Fatty Acids in Subjects Receiving Fish Oil Supplements and Followed for Seven Years”, (1992) Lipids, vol. 27, No. 7, pp. 533-538.
Gylling, Helena, et al., “Sitostanol ester margarine in dietary treatment of children with familial hypercholesterolemia” (1995) Journal of Lipid Research, vol. 36, pp. 1807-1812.
Gylling, H., et al., “Serum cholesterol and cholesterol and lipoprotein metabolism in hypercholesterolaemic NIDDM patients before and during sitostanol ester-margarine treatment”, (1994) Diabetologia 37:773-780.
Vanhanen, H., “Cholesterol malabsorption caused by sitostanol ester feeding and neomycin in pravastatin-treated hypercholesterolaemic patients”, (1994), Eur. J. Clin. Pharmacol., 47:169-176.
Denke, Margo A., “Lack of efficacy of low-dose sitostanol therapy as an adjunct to a cholesterol-lowering diet in men with moderate hypercholesterolemia1-3”, (1995) Am. J. Clin. Nutr. 61:392-6.
Tilvis, Reijo S., “Serum plant sterols and their relation to cholesterol absorption1.2”, (1986), The American Journal of Clinical Nutrition, 43:92-97.
Moghadasian, Mohammed H., et al., “Tall Oil”—Derived Phytosterols Reduce Atherosclerosis in ApoE-Deficient Mice, (1997), vol. 17(1), pp. 119-126.
“Dietary Supplementation with n-3 Polyunsaturated Fatty Acids and Vitamin E after Myocardial Infarction: Results of the GISSI-Preventione Trial,”The Lancet, 354:447-455 (1999).
“Randomised Trial of Cholesterol Lowering in 4444 Patients with Coronary Heart Disease: The Scandinavian Simvastatin Survival Study (4S),”The Lancetvol. 344, Nov. 19, 1383-1389 (1994).
Burr, M.L. et al., “Effects of Changes in Fat, Fish, and Fibre Intakes on Death and Mycocardial Reinfarction: Diet and Reinfarction Trial (Dart),”The Lancet, 757-761 (1989).
Carey, Martin C. et al., “Lipid Digestion and Absorption,”Ann. Rev. Physiol. 45:651-77 (1983).
Connor, Sonja L. et al., “Are Fish Oils Beneficial in the Prevention and Treatment of Coronary Artery Disease?”Am. J. Clin. Nutr. 66 (Suppl.): 1020S-31S (1997).
Criqui, M.H., “Triglycerides and Cardiovascular Disease, A Focus on Clinical Trials,”European Heart Journal19 (Supplement A); A36-A39.
Eisenberg, Daniel, “The Importance of Lowering Cholesterol in Patients with Cornary Heart Disease,”Clin. Cardiol. 21:81-84 (1998).
Franceschini, G. et al, “Pharmacological Control of Hypertriglyceridemia,” (1993)Cardiovas. Drugs Ther., 7, 297-302.
Gotto, Antonio M., Jr., “Triglyceride, The Forgotten Risk Factor,”Circulation, 97: 1027-1028 (1998).
Grundy, Scott M., “Hypertiglyceridemina, Atherogenic Dyslipidemia, and the Metabolic Syndrome,”American Journal of Cardiology, 81 (4A): 18B-25B (1998).
Grundy, Scott M., “Small LDL, Atherogenic Dyslipidemia, and the Metabolic Syndrome,”Circulation95:1-4 (1997).
Guido Franceschini and Rodolfo Paoletti, “Pharmacological Control of Hypertriglyceridemia,”Cardiovascular Drugs and Therapy, 1993:7:297-302 (1993).
Harris, William S., “Fish Oils and Plasma Lipid and Lipoprotein Metabolism in Humans: A Critical Review,”Journal of Lipid Research, 30:785-807 (1989).
Heinemann T. et al., “Effect of Low-Dose Sitostanol on Serum Cholesterol in Patients with Hypercholesterolemia,”Arethrosclerosis61:216-223 (1986).
Heinemann,
Kralovec Jaroslav A.
Wright Jeffrey L. C.
Needle & Rosenberg P.C.
Ocean Nutrition Canada Limited
Puttlitz Karl
Richter Johann
LandOfFree
Nutritional supplement for lowering serum triglyceride and... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Nutritional supplement for lowering serum triglyceride and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Nutritional supplement for lowering serum triglyceride and... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3650697