Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Genetically modified micro-organism – cell – or virus
Patent
1990-11-09
1993-03-02
Robinson, Douglas W.
Drug, bio-affecting and body treating compositions
Whole live micro-organism, cell, or virus containing
Genetically modified micro-organism, cell, or virus
426 18, 426 20, 426 21, 435209, A01K 6300, A61K 3700, C12N 942, A21D 200
Patent
active
051907550
DESCRIPTION:
BRIEF SUMMARY
The present invention relates to a nutrient composition for administration to patients, inter alia for feeding by tube, and for use as a health drink, or as a nutrient for horses, as well as to a method for the preparation of such a nutrient composition.
One medical problem in major operations of the abdomen is the general collapse of the organs due to infections from the large intestine. One way of reducing the risks of infections is to feed the patient by tube, thereby to keep the intestine working. This method imposes special demands on the tube-administered nutrient. Not only must the nutrient be nutrimentally complete; it must also be so thin-bodied that it can be administered via a thin plastics catheter, without necessitating a daily supply of more than 2-3 liters of liquid.
Furthermore, it is a great advantage if the nutrient can affect the composition of the patient's intestinal flora which frequently is disturbed in newly operated patients, and this may sometimes result in symptoms of poisoning. This applies especially to patients who have been or are being treated with antibiotics.
A further field of application where there is a need for specific nutrients is horse-racing. Horses, under stress, for example in connection with a race, frequently contract diarrhoea, which may affect their performance.
Present-day nutrient compositions used for feeding by tube substantially consist of fractionated food components recombined according to the recommendations of dieticians. The known nutrient compositions suffer from a number of shortcomings. If they have a suitable low viscosity for administration through narrow tubes, their concentration of the requisite nutrients will instead be too low, and therefore very large amounts must be given. Furthermore, the known nutrient compositions have a disagreeable taste and do not affect the patient's intestinal flora.
Indicia showing that certain intestine-specific lactobacilli have a special ability to counteract the establishment of undesired microorganisms in the intestine, have been reported by, for example, Wallstrom et al, 1987, J. Appl. Bacteriol. 62:513-520; Sherwood et al, 1987, Lancet, Dec. 26, 1519.
It is an object of the present invention to provide a nutrient composition for administration to patients, inter alia in feeding by tube, or for use as a health drink, said composition having a viscosity which is suitable for administration by tube, which is tasty, and which, furthermore, contains lactobacilli suitable for the intestine.
The nutrient composition according to the invention, especially when it contains fermented oats, is also highly suitable for administration to horses before a race for the prevention of diarrhoea.
A further object of the invention is to provide a method of preparing a nutrient composition for administration to patients, inter alia for feeding by tube, or for use as a health drink.
The nutrient composition according to the invention comprises a fermented cereal-based product, enzymes and, optionally, further nutrient components, in combination with lactobacilli.
The method according to the invention is characterised in that cereal flour is mixed with water and .alpha.-amylase, and that the mixture is brought to the boil under agitation, allowed to cool and mixed with .beta.-glucanase which is allowed to act until the viscosity of the mixture has decreased to below 0.020 Pas, whereupon the mixture is fermented.
A patient who is fed by tube can be supplied with the suitable lactobacilli in basically three different ways, viz. (i) the desired lactobacillus can be utilised for fermenting the product; (ii) a lactobacillus culture can be added separately to the fermented product; and (iii) the lactobacillus culture and the rest of the nutrient composition can be administered separately.
The lactobacillus desired in the final product is preferably used already for fermenting the product, whereby there is conveniently obtained a fermented product containing the desired culture, without necessitating the addition of further bacteria c
REFERENCES:
patent: 2194672 (1940-03-01), Porter
patent: 2452534 (1948-11-01), Jeffreys
patent: 4056637 (1977-11-01), Hagiwara
Albertsson Carl-Erik
Bengmark Stig
Larsson Kare
Molin Nils
Probi AB
Robinson Douglas W.
Williams Jane A.
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