Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1990-10-19
1992-07-28
Schain, Howard E.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
426656, A61K 3702, C07K 506
Patent
active
051341255
DESCRIPTION:
BRIEF SUMMARY
TECHNICAL FIELD
The present invention relates to nutrient compositions for mammals, and more particularly, to nutrient compositions comprising L-glutamyl-L-glutamine.
BACKGROUND ART
Humans and other mammals require daily intake of proteins for their life activities. Proteins are converted into amino acids in the digestive tract and utilized in vivo for growth, reproduction, assimilation, etc.
However, it is often difficult to take nutrients from ordinary foods under conditions such as postoperative lowering of function of the digestive tract and malnutrition due to apastia, starvation, etc., where nutrient supplementation is required. In addition, during or after hard physical labor or exercise, etc., metabolic function is enhanced and nitrogen is seriously lost by perspiration, and thus nutrient supplementation is necessary. In such cases, large quantities of proteins or amino acids must be taken in a readily absorbable form with minimized burden on the digestive tract.
Conventional methods for nutrient supplementation include intravenous injection and instillation of amino acids, and oral or intra-intestinal administration of nutrient compositions containing proteins of good quality such as meat extract, casein and albumen, amino acids, peptides, etc.
However, the use of some kinds of amino acids is limited because of their poor solubility, instability, etc. In particular, it is pointed out that supplementation of L-glutamine is necessary for a patient in postoperative catabolic condition since L-glutamine in the muscle of such a patient seriously decreases; but L-glutamine itself cannot be contained in known nutrient compositions which are sterilized by heating in the preparation process since it is unstable in solution and also has a poor stability to heat.
In order to supply L-glutamine which is unstable in solution as a nutrient composition for mammals, there have been developed nutrient compositions comprising L-glutamine in the form of .alpha.-L-aspartyl-L-glutamine (Japanese Published Unexamined Pat. Application No. 151156/1987), nutrient compositions comprising L-glutamine in the form of glycyl-L-glutamine (Japanese Published Unexamined Pat. Application No. 140923/1981), etc., by converting L-glutamine into a dipeptide.
Further, there is a report on the behavior of L-alanyl-L-glutamine in plasma and the uptake thereof by organs in Clinical Science, 75, 463 (1988).
In the nutrient compositions comprising .alpha.-L-aspartyl-L-glutamine or glycyl-L-glutamine, the stability of L-glutamine is considerably improved, but still they should be improved in many points such as stability under sterilizing conditions, absorption in vivo and utilization efficiency in vivo.
Further, when nutrient compositions comprising L-glutamine-containing dipeptides instead of L-glutamine are taken, these dipeptides must be hydrolyzed to amino acids in vivo. Conventionally used dipeptides were improved in stability of L-glutamine to heat, etc. but are not satisfactory in absorption in vivo and utilization efficiency in vivo.
DISCLOSURE OF THE INVENTION
The present inventors have found that by the use of L-glutamyl-L-glutamine instead of L-glutamine-containing dipeptides used heretofore, absorption, utilization efficiency, etc. of dipeptide in vivo can be improved as compared with conventional nutrient compositions, and have accomplished the present invention.
The present invention provides nutrient compositions comprising L-glutamyl-L-glutamine.
The present invention is described in detail below.
The nutrient compositions comprising L-glutamyl-L-glutamine are used mainly as nutrient compositions for oral or intra-intestinal administration.
In the case of oral administration, nutrient additives such as readily digestible carbohydrates, fats, vitamins and minerals may be added to the compositions to adjust the nutrient balance. Further, tasting and flavoring agents such as pseudo-tasting agents, sweeteners, flavors and dyes, appearance-improving agents, etc. may also be added to improve flavor of the compositions for o
REFERENCES:
patent: 4024286 (1977-05-01), Cornelius et al.
patent: 4340592 (1982-07-01), Adibi
Stehle et al. The Lancet Feb. 4, 1989 pp. 231-233.
Hubl et al. Metabolism, vol. 38, No. 8 Suppl 1 (Aug.) 1989 pp. 59-62.
Taniguchi et al. JBC, vol. 253, No. 6 (Mar. 1978) pp. 1799-1806.
Albers et al. Clinical Science (1988) 75 pp. 463-468.
Furukawa Tadayasu
Hara Takahiro
Koh Choon P.
Kyowa Hakko Kogyo Co. Ltd.
Schain Howard E.
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