Drug – bio-affecting and body treating compositions – Plant material or plant extract of undetermined constitution... – Containing or obtained from a fruit – including berry
Reexamination Certificate
2002-10-30
2004-05-04
Tate, Christopher R. (Department: 1654)
Drug, bio-affecting and body treating compositions
Plant material or plant extract of undetermined constitution...
Containing or obtained from a fruit , including berry
C424S725000, C426S599000
Reexamination Certificate
active
06730333
ABSTRACT:
BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates to nutraceutical compositions derived from the fruit of the
Garcinia mangostana L
. plant, otherwise known as the mangosteen plant. More particularly, the present invention relates to nutraceutical compositions comprising a mixture of the pulp and pericarp of the mangosteen fruit.
2. Background and Related Art
The mangosteen tree (
Garcinia mangostana L
.) was named after the French explorer Laurent Garcin (1683-1751) and has been cultivated for a considerable time in tropical areas of the world. The tree is presumed to have originated in South-east Asia or Indonesia and has largely remained indigenous to the Malay Peninsula, Myanmar, Thailand, Cambodia, Vietnam, the Sunda Islands, and the Moluccas. Although the mangosteen fruit is highly praised as one of the best tasting of all tropical fruits, it is considered a minor tropical fruit, and the mangosteen tree has largely piqued purely botanical interests over the years.
The mangosteen tree is a slow-growing, smooth evergreen tree that ranges from 5 to 25 meters in height with a flaking black bark that contains a yellow, resinous latex. The mangosteen tree bears fruit when 6 to 20 years old, depending on location, and can continue to yield fruit for up to 100 years. The mangosteen fruit ripens to a dark reddish-violet to black-violet color and is normally smooth or marked with brownish scars. The pericarp, or rind, of the mangosteen fruit is thick, tough, and exudes a bitter yellowish resin. Only about 25 to 30% of the mangosteen fruit consists of the edible pulp or rind, with the remainder comprising the tough, bitter pericarp. Each mangosteen fruit usually varies in weight from 75 to 120 grams and normally contains 2 to 3 well-developed seeds.
Over the years, the mangosteen plant has been used in a number of different ways. The timber is used for cabinets, building materials, fencing and furniture. The pericarp, containing pectin, tannins, resins and a yellow latex, is used in tanning and dyeing leather black. The fruit pulp is mostly used as a dessert, but can also be canned or made into preserves. However, when removing the fruit pulp from the rind, care must be taken to prevent the tannins and resins of the cut pericarp from contacting the fruit pulp. The mangosteen rind, leaves and bark have also been used as ingredients in folk medicine in areas where the plant grows indigenously. The thick mangosteen rind is used for treating catarrh, cystitis, diarrhea, dysentery, eczema, fever, intestinal ailments, itch, and skin ailments. The mangosteen leaves arc used by some natives in teas and other decoctions for diarrhea, dysentery, fever, and thrush. It is also known that concoctions of mangosteen bark can be used for genitourinary afflictions and stomatosis.
Some of the medicinal properties of the
Garcinia mangostana L
. plant have been the subject of pharmacological and clinical studies. These studies have isolated chemical constituents in the mangosteen leaves, wood, pericarp and seed aril, which were found to contain the following biologically active compounds, among others: 1,6-dihydroxy-3-methoxy-2-(3-methyl-2-butenyl) xanthone, 1,5,8-trihydroxy-3-methoxy-2-(3-methyl-2-butenyl) xanthone, maclurin, 1,3,6,7-tetrahydroxy xanthone, 1,3,6,7-tetrahydroxy xanthone-O-&bgr;-D-glucoside, chrysanthemin, cyaniding-3-O-&bgr;-D-sophoroside, 8-deoxygartanin, 1,5-dihydroxy-2-isopentenyl-3-methoxy xanthone, 1,7-dihydroxy-2-isopentenyl-3-methoxy xanthone, 5,9-dihydroxy-8-methoxy-2,2-dimethyl-7-(3-methylbut-2-enyl)2(H), 6(H)-pyrano-(3,2,6)-xanthen-6-one, fructose, garcinone A,B,C, D and E, gartanin, glucose, cis-hex-3-enyl acetate, 3-isomangostin, 3-isomangostin hydrate, 1-isomangostin, 1-isomangostin hydrate, kolanone, mangostin, &bgr;-mangostin, &agr;-mangostin, mangostin-3,6-di-O-gulcoside, normangostin, sucrose, tannins, BR-xanthone-A, BR-xanthone-B, calabaxanthone demethylcalabaxanthone,2-(&ggr;,&ggr;-dimethylallyl)-1,7-dihydroxy-3-methoxyxanthone, 2,8-bis-(&ggr;,&ggr;-dimethylallyl)-1,3,7-trihydroxyxanthone, 1,3,5,8-tetrahydroxy-2,4-diprenylxanthone, and mangostanol. Many of these chemical constituents are xanthones, which are biologically active compounds that are receiving increasing interest in pharmacological studies for a variety of health benefits.
However, despite the pharmacological benefits of individual xanthone compounds and the native medicinal uses of the bark, leaves and rind of the mangosteen plant in Southeast Asia and Indonesia, a nutraceutical composition containing the holistic benefits of the entire mangosteen fruit, including the fruit pulp and pericarp, is not known. In fact, it is recognized that when preparing the fruit pulp for consumption, care should be taken to separate from the delicious inner fruit pulp the outer pericarp with its resins and tannins, which are traditionally used to treat and stain leathers.
There exists a need in the nutritional arts for a nutraceutical composition that offers the health benefits of the entire mangosteen fruit, including the pulp and the pericarp. There also exists a need for a nutraceutical composition rich in natural xanthones for treating a variety of human ailments and conditions in an efficacious manner. Further, there is a need in the art for a natural xanthone product that is economical to manufacture.
SUMMARY OF THE INVENTION
The present invention relates to nutraceutical compositions derived from the fruit of the
Garcinia mangostana L
., or mangosteen plant. More particularly, the present invention relates to efficacious nutraceutical compositions rich in natural xanthones that include the pulp and the pericarp of the mangosteen fruit. These compositions preferably comprise a mixture of mangosteen fruit pulp and pericarp with selected juice concentrates. In addition, the present invention relates to methods of preparing nutraceutical compositions of
Garcinia mangostana L
. plant that yield efficacious health supplements rich in natural xanthones. Further, the methods of preparing the mangosteen nutraceutical compositions are economical to operate.
A primary object of the present invention is to provide a nutraceutical composition that contributes to general human wellness and good health through a novel mixture of the pericarp and pulp of the fruit of the
Garcinia mangostana L
. plant. The effectiveness of this mixture is heightened through the addition of selected juice concentrates in varying amounts.
Another object of the present invention is to provide a nutraceutical composition that offers the holistic benefits of the entire mangosteen fruit and is an efficacious source of natural xanthone compounds.
An additional object of the present invention is to provide an antimicrobial and anti-inflammatory composition containing a therapeutic amount of natural xanthones derived from the
Garcinia mangostana L
. plant.
A further object of the present invention is to provide a xanthone-rich natural product with antioxidative properties.
Another object of the present invention is to provide a nutraceutical composition of
Garcinia mangostana L
. plant with beneficial antibacterial action.
An additional object of the present invention is to provide a process for preparing nutraceutical compositions of the
Garcinia mangostana L
. plant yielding the holistic benefits of the unique combination of mangosteen fruit pulp and pericarp, either alone or with complementary and enhancing juice concentrates.
Yet another object of the present invention is to provide an economical process for manufacturing nutraceutical compositions of the entire fruit of the
Garcinia mangostana L
. plant.
The foregoing and other objects, advantages and characterizing features will become apparent from the following description of certain illustrative embodiments of the invention.
While the methods and processes of the present invention have proven to be particularly useful in the area of nutritional health supplements, those skilled in the art can appreciate that the methods and processes can be used in a va
Garrity Aaron R.
Morton Gordon A.
Morton Joseph C.
Bean Stephen H.
DBC, LLC
Tate Christopher R.
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