Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1988-06-17
1990-02-06
Friedman, Stanley J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514561, A61K 31195, A61K 31415
Patent
active
048988790
ABSTRACT:
Nutritional compositions for management of hepatic failure are improved by eliminating certain ammonotelic amino acids and reducing the proportion of essential ammonotelic amino acids. A composition is provided which is optimized for nutritional therapy and suppression of hyperammonemia.
REFERENCES:
patent: 3697287 (1984-07-01), Wintz
patent: 3950529 (1976-04-01), Fischer et al.
Dickerson, "Nutritional Support Update" American Druggest, Oct. 1985, pp. 144-149.
Nance et al., "Eck's Fistula Encephalopathy in Germ Free Dogs", Ann. Surg. vol. 174 (5) 856-862 (11/71).
Ghadimi, "Acid-Base Problens After Intravenous Amino Acids", New Eng. J. Med. vol. 288 (8): 420-421 (1973).
Greenburger et al., "Effect of Vegetable and Animal Protein Diets in Chromic Hepatic Encephalopathy", Am. J. Dig. Div. vol. 22 (10): 845-855 (1977).
Zieve, "Amino Acid in Liver Failure", Gastroenterology, vol. 26 No 1 219-221 (01/79).
Zieve, "Pathogenesis of Hepatic Coma", 118 Arch. Inter Med. 211 (1966).
Fischer et al., "False Neurotransmitters and Hepatic Failure", The Lancet 75-79 (71).
Aguirre et al., "Plasma Amino Acids in Dogs with Two Expermental Forms of Liver Damage", J. of Sur. Res., vol. 16. No. 4, p. 339 (1974).
Fischer et al., "Plasma Amino Acids in Patients with Hepatic Encephalipathy", Am. J. Sur., vol. 127 p. 40 (1974).
Fischer et al., "The Effect of Normalization of Plasma Amino Acids on Hepatic Encephalopathy in Man", vol. 80, No. 1, p. 77-92 (07/76).
Rosen et al., "Plasma Amino Acid Patterns in Hepatic Encephalopathy of Differing Etiology", Gast., vol. 72 p. 483 (1977).
Maddrey et al., "Chronic Hepatic Encephalopathy", Mod. Cl. N. Amer., vol. 59, No. 4 p. 937 (1975).
Smith et al., "Alterations in Plasma CSF Amino Acids, Amines, and Meabolites in Hepatic Coma", Ann. Sur., vol. 187 No. 3, p. 343 (1978).
Iob et al., "Alterations in Plasma-Free Amino Acids in Dogs with Hepatic Insufficiency", Sur. p. 766 (05/70).
Ogihara et al., "Tryptohan as Cause of Hepatic Coma", New Eng. J. of Med., vol. 275, No. 22, p. 1255 (1966).
Wu et al., "Changes in Free Amino Acids in the Plasma During Hepatic Coma", p. 845 (1955).
Iber et al., "The Plasma Amino Acids in Patients with Liver Failure", J. Lab. & Clin. p. 417 (1957).
Mattson et al., "Alterations in Individual Free Amino Acids in Brain During Acute Hepatic Coma", Srugery p. 263 (1970).
Vinnars et al., "The Nutrition Effect in Man of Non-Essential Amino Acids Infused Intravenously Together with the Essential Ones", Acta. anesth, Scandina., vol. 14, pp. 259-271 (1970).
Hirayama, "Trypotophan Metabolism in Liver Disease", Clinica Chmica Acta 32 p. 191 (1971).
Rudman et al., "Obersations in Nitrogen Metabolism of Patients with Portue Ciffhosis", A. J. Clin, Nut., vol. 23, p. 1203 (09/70).
Levine et al., "Tyrosine Metabolism in Patients with Liver Disease", J. Clin. Inv., vol. 46, p. 2012 (1967).
Rose, "Amino Acid Requirements in Man", Federation Proceedings p. 546.
Perez-Cruet et al., "Dietary Regulation of Brain Tryophan Metabolism by Plasma Ratio of Free Tryophan and Neutral Amino Acids in Humans", Nature, vol. 248, p. 693 (1976).
Madsen David C.
Tucker Hugh N.
Baxter International Inc.
Fentress Susan Bennett
Flattery Paul C.
Friedman Stanley J.
Hartenberger Robert E.
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