Number coding for identification of subtypes of coded types...

Details Number coding for identification of subtypes of coded types... Number coding for identification of subtypes of coded types...

2011-04-19

2011-04-19

Moran, Marjorie (Department: 1631)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C435S091100, C536S024300, C436S523000, C422S068100, C702S020000

Reexamination Certificate

active

07927796

ABSTRACT:
Disclosed is number coding of pairs (“doublets”) or small sets (“multiplets”) of solid phase carriers which provides distinguishable subtypes of a given type of such carriers, where each carrier type is distinguishable on the basis of a different code. Such number coding is useful for augmenting a coding system, such as a color code, and thereby effectively multiplying the number of “colors” (distinguishable sub-types). It can be applied, for example, to determine whether a sample is homozygous or heterozygous at a number of different sites for one of two different alleles, where the same color code is applied for each of the two alleles, and the alleles with the same color code are distinguished by knowing how many carriers are associated with molecules which detect each different allele.

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Michael et al., Randomly Ordered Addressable High-Density Optical Sensor Arrays, Anal. Chem. 1999, 70, 1242-1248.

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