Numb protein expression inhibitors by Musashi

Details Numb protein expression inhibitors by Musashi Numb protein expression inhibitors by Musashi

2007-09-04

2007-09-04

Kaushal, Sumesh (Department: 1633)

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

C514S002600, C435S069100, C435S320100, C435S325000, C435S455000

Reexamination Certificate

active

10343311

ABSTRACT:
An Numb protein expression inhibitor comprising, as active ingredient, Musashi protein, a polypeptide having an amino acid sequence obtained by replacement, deletion, addition or insertion of at least one amino acid in an amino acid sequence of Musashi protein, or a gene encoding said polypeptide.By the present invention, a new function of Musashi protein has been elucidated. Described specifically, Musashi protein inhibits expression of Numb protein having a neuronal differentiation regulating function and potentiates the activity of the Notch signaling system, so that Musashi protein can be used as a therapeutic for various diseases of the central nervous system.

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