Nucleotides coding for the extracellular membrane-bound segment

Details Nucleotides coding for the extracellular membrane-bound segment Nucleotides coding for the extracellular membrane-bound segment

1993-10-22

1996-01-16

Budens, Robert D.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435 696, 4352402, 43525233, 4353201, 5303871, C07H 2104, C07H 2102, C07H 2100

Patent

active

054849071

ABSTRACT:
The invention relates to epitopes which are present on B cell-bound but not secreted IgA, peptide segments which represent such epitopes, and DNA coding for these peptides. These extracellular peptide segments form, entirely or in part, antigenic epitopes unique to membrane-bound but not secreted IgA.

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Alt et al., "Synthesis of Secreted and Membrane-Bound Immunoglobulin Mu Heavy Chains Is Directed by mRNAs That Differ at Their 3' Ends," Cell 20: 293-301, Jun. 1980.
Early et al., "Two mRNAs Can Be Produced From A Single Immunoglobulin .mu. Gene by Alternative RNA Processing Pathways," Cell 20:313-319, Jun. 1980.
McCune et al, "Biogenesis of Membrane-Bound and Secreted Immunoglobulins II," J. Exp Med 153:1684-1689, June 1981.
Sitia et al., "Membrane-Bound and Secreted IgA Contain Structurally Different .alpha. Chains," J. Immunol. 128(2):712-716.
Ward et al., "The Murine Immunoglobulin .alpha. Gene Expresses Multiple Transcripts From a Unique Membrane Exon," EMBO J. 2(6):887-898, 1983.
McCune et al, "Membrane-Bound and Secreted Immunoglobulins I," J. Exp Med. 152:463-468, Aug. 1980.

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