Nucleotides and oligonucleotides preparable therefrom

Details Nucleotides and oligonucleotides preparable therefrom Nucleotides and oligonucleotides preparable therefrom

1997-01-31

2000-09-12

Wilson, James O.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 231, 536 245, 536 253, 536 256, 536 276, 536 2781, 536 285, 536 2854, 536115, 536118, C07H 1900

Patent

active

061179884

ABSTRACT:
Analogues of RNA and DNA compounds contain a neutral, stereoregular linking group based on replacement of the phosphoryl with a sulfonyl group. Precursors to the analogues are also described, as are methods for preparing the precursors and analogues.

REFERENCES:
patent: 5470967 (1995-11-01), Huie et al.
patent: 5536823 (1996-07-01), Widlanski
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J. Huang, E.B. McElroy, T.S. Widlanski, "Synthesis Of Sulfonate-Linked DNA", J. Organic Chem., vol. 59, No. 13, pp. 3520-3521 (1994).
E.B. McElroy, R. Bandaru, J. Huang, T.S. Widlanski, "Synthesis And Physical Properties Of Sulfonamide-Containing Oligonucleotides", Biorganic & Medicinal Chemistry Letters, vol. 4, No. 3, pp. 1071-1076 (1994).
Mirabelli et al., Anti Cancer Drug Design, vol. 6, pp. 647-661 (1991).
Uhlmann et al., Chemical Reviews, vol. 90, No. 4, pp. 544-584, (1990).
Musicki et al., Tetrahedron Letters, vol. 32, No. 10, pp. 1267-1270 (1991).
Reynolds et al., J. Org. Chem, vol. 57, No. 11, pp. 2983-2985 (1992).

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