Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1997-10-01
2000-10-17
Achutamurthy, Ponnathapu
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
435325, 4353201, 435 6, 536 231, C07K 100, C12N 500, C12N 1500, C12Q 168
Patent
active
061334197
ABSTRACT:
Identification, characterization and expression of nucleotides that encode phosphatidylinositol-3' kinase associated protein(s) that bind to the intermediate SH2 domain on the regulatory subunit of PI3K, p85, by the associated protein(s) C-terminal amino acids, and that exhibit a bromodomain are described, as well as methods of using such proteins for medical applications, including diagnosis and treatment cell growth disorders.
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Stephens, et al., "Agonist-Stimulated Synthesis of Phosphatidylinositol(3,4,5)-Trisphosphate: A New Intracellular Signalling System?", (1993) Elsevier Science Publishers B.V., p. 27-75.
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Matsui et al. "Isolation of a Novel Receptor cDNA Establishes the Existence of Two PDGF Receptor Genes" Science, vol. 243, Sep. 1998 pp. 800-804.
Ueno et al. "Inhibition of PDGF Beta Receptor Signal Transduction by Coexpression of a Truncated Receptor" Science, vol. 252, Jan. 1991 pp. 844-848.
Shurtleff et al., "Structural features of the colony-stimulating factor 1 receoptor that affect its association with phosphatidylinositol 3-kinase" Oxford University Press, Mar. 1990 pp. 2415-2421.
Achutamurthy Ponnathapu
Giotta Gregory
ONYX Pharmaceuticals, Inc.
Tung Peter P.
LandOfFree
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