Nucleotide sequences that encode deregulated...

Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for...

Reexamination Certificate

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C435S190000, C435S194000, C435S116000

Reexamination Certificate

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07732176

ABSTRACT:
The invention relates to nucleotide sequences of coryneform bacteria that encode proteins that are involved in the biosynthesis of L-serine and to a method for producing L-serine. According to the invention, at least 79 amino acids at the C terminus of the wild-type serA sequence are deleted, thereby producing a 3-phosphoglycerate dehydrogenase having a reduced feedback inhibition by L-serine vis-à-vis the wild-type sequence.

REFERENCES:
patent: 5624828 (1997-04-01), Katsumata et al.
patent: 6037154 (2000-03-01), Suga et al.
patent: 6180373 (2001-01-01), Wich et al.
patent: 6258573 (2001-07-01), Suga et al.
patent: 0 943 687 (1999-09-01), None
Bell et al. De-regulation of D-3-phosphoglycerate dehydrogenase by domain removal. Eur. J. Biochem. 269, 4176-4184 (2002).
“3-Phosphoglycerate dehydrogenase . . . ” by Peters-Wendisch et al. (Appl.Microbiol Biochtenol. (2002).
XP-001155222 ( C-terminal deletion . . . ) published by Elsevier Scioence Publishers 1991.
XP-002255655 published Oct. 2001.
XP-002255645 publiocation date Sep. 2002.

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