Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1996-01-23
1998-05-19
Jones, W. Gary
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
536 231, 536 2432, C12P 2100, C07H 2104, C07H 2102
Patent
active
057534594
ABSTRACT:
Antigenic rare outer membrane proteins of Spirochaetaceae are obtained from organisms extracted from infected tissue by a novel process of isolation utilizing a discontinuous Ficoll gradient separation, release of outer membrane in a low isotonic and low pH buffer and identification of outer membrane by use of a lipid soluble dye. Four antigenic rare outer membrane proteins of T. pallidum subsp. pallidum useful in diagnosis and prophylaxis of syphilis are provided. Also provided are the amino acid sequences of two rare outer membrane proteins of T. pallidum subsp. pallidum, called TROMP 1 and TROMP 2, and the nucleotide sequences encoding them.
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Blanco David R.
Champion Cheryl I.
Lovett Michael A.
Miller James N.
Tempst Paul J.
Atzel Amy
Jones W. Gary
Sloan-Kettering Institute for Cancer Research
The Regents of the University of California
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