Nucleotide sequences encoding a thermostable alkaline protease

Details Nucleotide sequences encoding a thermostable alkaline protease Nucleotide sequences encoding a thermostable alkaline protease

1996-10-23

1998-01-06

Wax, Robert A.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

435220, 4352523, 4352535, 4353201, 536 232, C12N 952, C12N 950, C12N 120, C07H 2104

Patent

active

057053790

ABSTRACT:
Nucleotide sequences, derived from a thermophilic actinomycete microorganism, which encode a thermostable alkaline protease are disclosed. Also disclosed are variants of the nucleotide sequences which encode a polypeptide having thermostable alkaline proteolytic activity. Recombinant thermostable alkaline protease or recombinant polypeptide may be obtained by culturing in a medium a host cell genetically engineered to contain and express a nucleotide sequence according to the present invention, and recovering the recombinant thermostable alkaline protease or recombinant polypeptide from the culture medium.

REFERENCES:
patent: 5192677 (1993-03-01), Kinsella et al.
Kristjansson and Kinsella, "Heat Stable proteinase from Thermomonospora fusca", Int. J. Peptide Protein Res. 36:201-207, 1990.

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